Individualized Exercise Training at Maximal Fat Oxidation Combined with Fruit and Vegetable-Rich Diet in Overweight or Obese Women: The LIPOXmax-Réunion Randomized Controlled Trial

• Published in: PloS one 2015-11, Vol.10 (11), p.e0139246-e0139246
• Main Authors: Besnier, Florent, Lenclume, Victorine, Gérardin, Patrick, Fianu, Adrian, Martinez, Jérémy, Naty, Nadège, Porcherat, Sylvaine, Boussaid, Karim, Schneebeli, Stéphane, Jarlet, Eric, Hatia, Sarah, Dalleau, Georges, Verkindt, Chantal, Brun, Jean-Frédéric, Gonthier, Marie-Paule, Favier, François
• Format: Article
• Language: English
• Subjects: Adipose Tissue - metabolism; Adipose Tissue - pathology; Adult; Anthropometry; Biochemistry; Biochemistry, Molecular Biology; Blood Glucose - analysis; Body Composition; Body fat; Body mass; Body mass index; Body size; Body weight; Carbohydrate Metabolism; Cholesterol; Clinical trials; Combined Modality Therapy; Diabetes; Diabetes mellitus; Disease prevention; Endocrinology; Energy Metabolism; Exercise intensity; Exercise Test; Exercise Therapy; Fat-free body mass; Female; Fitness training programs; Follow-Up Studies; Food and Nutrition; Fruit; Fruits; Glucose; Hospitals; Humans; Insulin; Insulin - blood; Insulin Resistance; Intervention; Life Sciences; Lipid Metabolism; Lipids; Lipids - blood; Mens health; Metabolic disorders; Obesity; Obesity - diet therapy; Obesity - epidemiology; Obesity - pathology; Obesity - therapy; Overweight; Overweight - diet therapy; Overweight - epidemiology; Overweight - pathology; Overweight - therapy; Oxidation; Oxidation-Reduction; Physical activity; Physical fitness; Physical training; Physiology; Precision Medicine; Randomization; Reduction; Reunion - epidemiology; Training; Treatment Outcome; Triglycerides; Vegetables; Weight control; Womens health; Young Adult; Zeidae
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0139246

Lifestyle combined interventions are a key strategy for preventing type-2 diabetes (T2DM) in overweight or obese subjects. In this framework, LIPOXmax individualized training, based on maximal fat oxidation [MFO], may be a promising intervention to promote fat mass (FM) reduction and prevent T2DM. Our primary objective was to compare three training programs of physical activity combined with a fruit- and vegetable-rich diet in reducing FM in overweight or obese women. A five months non-blinded randomized controlled trial (RCT) with three parallel groups in La Réunion Island, a region where metabolic diseases are highly prevalent. One hundred and thirty-six non-diabetic obese (body mass index [BMI]: 27-40 kg/m2) young women (aged 20-40) were randomized (G1: MFO intensity; G2: 60% of VO2-peak intensity; G3: free moderate-intensity at-home exercise following good physical practices). Anthropometry (BMI, bodyweight, FM, fat-free mass), glucose (fasting plasma glucose, insulin, HOMA-IR) and lipid (cholesterol and triglycerides) profiles, and MFO values were measured at month-0, month-3 and month-5. At month-5, among 109 women assessed on body composition, the three groups exhibited a significant FM reduction over time (G1: -4.1±0.54 kg; G2: -4.7±0.53 kg; G3: -3.5±0.78 kg, p