Low Serum 25-Hydroxyvitamin D Levels Are Associated with Dry Eye Syndrome

• Published in: PloS one 2016-01, Vol.11 (1), p.e0147847-e0147847
• Main Authors: Yoon, Sam Young, Bae, Seok Hyun, Shin, Young Joo, Park, Shin Goo, Hwang, Sang-Hee, Hyon, Joon Young, Wee, Won Ryang
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Adult; Adults; Aged; Aged, 80 and over; Allergic diseases; Analysis; Anxiety; Arthritis; Atopic dermatitis; Autoimmune diseases; Biology and Life Sciences; Care and treatment; Cell adhesion & migration; Chronic pain; Complications and side effects; Confidence intervals; Cornea; Cross-Sectional Studies; Cytokines; Data analysis; Data collection; Data processing; Dermatitis; Diabetes; Diabetes mellitus; Dietary supplements; Disease; Dry eye syndromes; Dry Eye Syndromes - blood; Eczema; Exposure; Eye; Female; Gender; Health aspects; Health Surveys; Humans; Hyperlipidemia; Inflammation; Intestine; Irritable bowel syndrome; Male; Medicine; Medicine and Health Sciences; Mental depression; Middle Aged; Nutrition; Obesity; Occupations; Pain; Physical Sciences; Population; Quality of life; Rheumatoid arthritis; Risk analysis; Risk Factors; Suicides & suicide attempts; Sunlight; Surgery; Tearing; Thyroid; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin deficiency; Walking; Young Adult; Zinc
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0147847

Dry eye syndrome (DES) is a common tear film and ocular surface disease that results in discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. Systemic diseases associated with DES include diabetes mellitus, rheumatoid arthritis, depression, anxiety, thyroid disease, allergic diseases, irritable bowel syndrome, chronic pain syndrome, and hyperlipidemia. Interestingly, it has been found that most of these are associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) or inadequate sunlight exposure. In this cross-sectional data analysis, noninstitutionalized adults aged ≥19 years (N = 17,542) who participated in Korean National Health and Nutrition Examination Survey 2010-2012 were included. Information regarding duration of sunlight exposure was collected from the survey participants. Serum 25(OH)D and zinc levels were measured. The confounding variables were age, gender, sunlight exposure time, region of residence, obesity, serum 25(OH)D level, diabetes mellitus, rheumatoid arthritis, depression, thyroid disorder, atopic dermatitis, history of ocular surgery, regular exercise, and walking exercise. Mean serum 25(OH)D levels of subjects with and without DES were 16.90 ± 6.0 and 17.52 ± 6.07 (p