Hyperlipidemia Is Associated with Chronic Urticaria: A Population-Based Study

• Published in: PloS one 2016-03, Vol.11 (3), p.e0150304-e0150304
• Main Authors: Chung, Shiu-Dong, Wang, Kuo-Hsien, Tsai, Ming-Chieh, Lin, Herng-Ching, Chen, Chao-Hung
• Format: Article
• Language: English
• Subjects: Adult; Adults; Ambulatory care; Atherosclerosis; Beneficiaries; Biology and Life Sciences; Case-Control Studies; Chronic Disease; Complications and side effects; Confidence intervals; Copper; Cytokines; Databases, Factual; Dermatitis; Dermatology; Diagnosis; Earth Sciences; Etiology; Fatty acids; Female; Hives (Disease); Hospitals; Humans; Hyperlipidemia; Hyperlipidemias - complications; Hyperlipidemias - diagnosis; Hyperlipidemias - epidemiology; Inflammation; Inflammatory diseases; Informatics; Lipids; Male; Medicine and Health Sciences; Metabolic disorders; Metabolic syndrome; Middle Aged; Pathogenesis; Patients; Plasma; Population; Population studies; Population-based studies; Proteins; Regression analysis; Risk factors; Social Sciences; Statistical analysis; Taiwan - epidemiology; Thoracic surgery; Tumor necrosis factor-TNF; Urticaria; Urticaria - complications; Urticaria - diagnosis; Urticaria - epidemiology; Validity
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0150304

The etiology of chronic urticaria (CU) is diverse, with chronic infections and inflammation being reported as considerable contributing factors. Although the prevalence of metabolic syndrome was found to be significantly elevated in patients with CU, no one has specifically estimated the effects on CU following hyperlipidemia. This study aimed to examine the association between hyperlipidemia and CU using a population-based dataset in Taiwan. This study included 9798 adults with CU as cases and 9798 sex- and age-matched controls. These patients were examined for whether they had received a prior diagnosis of hyperlipidemia. We used conditional logistic regression analyses to calculate the odds ratio (OR) and its corresponding 95% confidence interval (CI) for having been previously diagnosed with hyperlipidemia between cases and controls. In total, 7066 (36.1%) patients had received a prior diagnosis of hyperlipidemia, including 4287 (43.8%) among CU cases and 2779 (28.4%) among controls. The conditional logistic regression revealed that the OR of prior hyperlipidemia for cases was 1.97 (95% CI: 1.85~2.09) compared to the controls. Furthermore, compared to patients without CU, patients with CU independently experienced a 1.65-fold (95% CI = 1.55~1.76; p