Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children

Respiratory syncytial virus (RSV) and influenza A viruses are known to cause severe acute respiratory tract infections (SARIs) in children. For other viruses like human rhinoviruses (HRVs) this is less well established. Viral or bacterial co-infections are often considered essential for severe manif...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0150776-e0150776
Main Authors: Moesker, Fleur M, van Kampen, Jeroen J A, van Rossum, Annemarie M C, de Hoog, Matthijs, Koopmans, Marion P G, Osterhaus, Albert D M E, Fraaij, Pieter L A
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Bacteria
Bacterial infections
Biology and Life Sciences
C-reactive protein
Causes of
Child
Child, Preschool
Children
Complications and side effects
Emergency medical care
Family medical history
Female
Health aspects
Hospitals
Hospitals, Pediatric
Humans
Infant
Infections
Influenza A
Influenza A virus
Influenza, Human - epidemiology
Intensive care
Laboratories
Male
Medicine and Health Sciences
Morbidity
Patients
People and Places
Physiological aspects
Pneumonia
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Viruses
Respiratory tract
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Rhinovirus
Risk factors
RNA-directed DNA polymerase
Severe acute respiratory syndrome
Severity of Illness Index
Streptococcus infections
Swine flu
Systematic review
Tertiary Care Centers
Viral Load
Viruses
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Summary:Respiratory syncytial virus (RSV) and influenza A viruses are known to cause severe acute respiratory tract infections (SARIs) in children. For other viruses like human rhinoviruses (HRVs) this is less well established. Viral or bacterial co-infections are often considered essential for severe manifestations of these virus infections. The study aims at identifying viruses that may cause SARI in children in the absence of viral and bacterial co-infections, at identifying disease characteristics associated with these single virus infections, and at identifying a possible correlation between viral loads and disease severities. Between April 2007 and March 2012, we identified children (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0150776