Investigation of Genetic Variation Underlying Central Obesity amongst South Asians

South Asians are 1/4 of the world's population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate t...

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Bibliographic Details
Published in:PloS one 2016-05, Vol.11 (5), p.e0155478-e0155478
Main Authors: Scott, William R, Zhang, Weihua, Loh, Marie, Tan, Sian-Tsung, Lehne, Benjamin, Afzal, Uzma, Peralta, Juan, Saxena, Richa, Ralhan, Sarju, Wander, Gurpreet S, Bozaoglu, Kiymet, Sanghera, Dharambir K, Elliott, Paul, Scott, James, Chambers, John C, Kooner, Jaspal S
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Asian people
Asians - genetics
Association analysis
Atherosclerosis
Biology and Life Sciences
Birth weight
Body mass
Body mass index
Body size
Country of birth
Data processing
Deoxyribonucleic acid
Diabetes
Disease
DNA
DNA methylation
Epidemiology
Epigenetics
Exome
Family medical history
Female
Gene Frequency
Genetic analysis
Genetic aspects
Genetic diversity
Genetic variance
Genetic Variation
Genetics
Genome-Wide Association Study
Genomes
Genomics
Genotype
Health risks
Health sciences
Heart
Hip
Hospitals
Humans
Insulin resistance
Loci
Male
Medicine and Health Sciences
Metabolic syndrome
Middle Aged
Nucleotide sequence
Obesity
Obesity, Abdominal - ethnology
Obesity, Abdominal - genetics
Physical Sciences
Physiological aspects
Polymorphism, Single Nucleotide
Population
Population genetics
Principal components analysis
Research and Analysis Methods
Risk
Risk Factors
Sequence Analysis, DNA
Single-nucleotide polymorphism
Studies
Whites - genetics
Young adults
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Description
Summary:South Asians are 1/4 of the world's population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analysis of population-specific SNPs; ii) an exome-wide association analysis of ~250K SNPs in protein-coding regions in 2,637 South Asians; iii) a comparison of risk allele frequencies and effect sizes of 48 known WHR SNPs in 12,240 South Asians compared to Europeans. In genome-wide analyses, we found no novel associations between common genetic variants and WHR in South Asians at P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0155478