Standing on the Shoulders of Giant Viruses: Five Lessons Learned about Large Viruses Infecting Small Eukaryotes and the Opportunities They Create

While a variety of arguments can be made for altering these metrics, what is clear is that these viruses bring with them a potential (in terms of genes that are transcribed and translated) that is historically associated with cellular life forms: this includes members of the Mimiviridae that infect...

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Bibliographic Details
Published in:PLoS pathogens 2016-08, Vol.12 (8), p.e1005752-e1005752
Main Authors: Wilhelm, Steven W, Coy, Samantha R, Gann, Eric R, Moniruzzaman, Mohammad, Stough, Joshua M A
Format: Article
Language:English
Subjects:
Algae
Biology and life sciences
DNA viruses
Eukaryota - virology
Funding
Genes
Genomes
Giant Viruses - physiology
Identification and classification
Laboratories
Medical research
Observations
Pearls
Research and Analysis Methods
Researchers
Studies
Viral infections
Virulence (Microbiology)
Viruses
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Description
Summary:While a variety of arguments can be made for altering these metrics, what is clear is that these viruses bring with them a potential (in terms of genes that are transcribed and translated) that is historically associated with cellular life forms: this includes members of the Mimiviridae that infect amoebas, as well as the "extended" phylogenetic group that infect algae [4]. [...]this includes (but is not limited to) central components of protein translation, parts of DNA repair pathways, polysaccharide synthesis enzymes, genes containing inteins, and, more recently, evidence for a genetic system that may offer protection against virion factory-infecting virophage [16].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005752