Kidney function and specific mortality in 60-80 years old post-myocardial infarction patients: A 10-year follow-up study

• Published in: PloS one 2017-02, Vol.12 (2), p.e0171868-e0171868
• Main Authors: Hoogeveen, Ellen K, Geleijnse, Johanna M, Giltay, Erik J, Soedamah-Muthu, Sabita S, de Goede, Janette, Oude Griep, Linda M, Stijnen, Theo, Kromhout, Daan
• Format: Article
• Language: English
• Subjects: Afdeling Humane voeding; Age; Aged; Aged, 80 and over; Analysis; Antihypertensives; Biology and Life Sciences; Cancer; Cardiovascular diseases; Care and treatment; Causes of; Chair Nutrition and Disease; Chronic kidney failure; Complications and side effects; Confidence intervals; Consortia; Creatinine; Cystatin C; Death; Diabetes; Diabetes mellitus; Drugs; Epidemiology; Epidermal growth factor receptors; Fatty acids; Female; Follow-Up Studies; Glomerular Filtration Rate; Health risk assessment; Health risks; Heart; Heart attack; Heart attacks; Heart diseases; HNE Nutrition and Disease; HNE Voeding en Ziekte; Human Nutrition; Human Nutrition & Health; Human Nutrition (HNE); Humane Voeding; Humane Voeding & Gezondheid; Humans; Hypertension; Kidney diseases; Laboratories; Male; Mathematical models; Medical prognosis; Medicine and Health Sciences; Meta-analysis; Middle Aged; Mortality; Myocardial infarction; Myocardial Infarction - complications; Myocardial Infarction - epidemiology; Myocardial Infarction - mortality; Nephrology; Netherlands; Nutrition; Nutrition and Disease; Patient outcomes; Patients; People and Places; Pharmacology; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - mortality; Renal Insufficiency, Chronic - pathology; Risk factors; Splines; Statins; Studies; Survival Analysis; VLAG; Voeding en Ziekte
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0171868

Chronic kidney disease (CKD) is highly prevalent among older post-myocardial infarction (MI) patients. It is not known whether CKD is an independent risk factor for mortality in older post-MI patients with optimal cardiovascular drug-treatment. Therefore, we studied the relation between kidney function and all-cause and specific mortality among older post-MI patients, without severe heart failure, who are treated with state-of-the-art pharmacotherapy. From 2002-2006, 4,561 Dutch post-MI patients were enrolled and followed until death or January 2012. We estimated Glomerular Filtration Rate (eGFR) with cystatin C (cysC) and creatinine (cr) using the CKD-EPI equations and analyzed the relation with any and major causes of death using Cox models and restricted cubic splines. Mean (SD) for age was 69 years (5.6), 79% were men, 17% smoked, 21% had diabetes, 90% used antihypertensive drugs, 98% used antithrombotic drugs and 85% used statins. Patients were divided into four categories of baseline eGFRcysC: ≥90 (33%; reference), 60-89 (47%), 30-59 (18%), and