Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport

This study was aimed to investigate the effect of human PON1 overexpression in mice on cholesterol efflux and reverse cholesterol transport. PON1 overexpression in PON1-Tg mice induced a significant 3-fold (p

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Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0173385-e0173385
Main Authors: Ikhlef, Souade, Berrougui, Hicham, Kamtchueng Simo, Olivier, Zerif, Echarki, Khalil, Abdelouahed
Format: Article
Language:English
Subjects:
ABC transporters
ABCA1 protein
Aging
Analysis
Animals
Apolipoproteins
Aryldialkylphosphatase - blood
Aryldialkylphosphatase - genetics
Atherosclerosis
ATP Binding Cassette Transporter 1 - metabolism
ATP-binding protein
Biological Transport
Biology and Life Sciences
Blood cholesterol
Cardiovascular disease
Cell Line
Cholesterol
Cholesterol, HDL - metabolism
Comparative analysis
Efflux
Gene Expression
High density lipoprotein
Homeostasis
Humans
Laboratory animals
Lipids
Liver X Receptors - metabolism
Low density lipoprotein
Macrophages
Macrophages, Peritoneal - cytology
Macrophages, Peritoneal - metabolism
Male
Medicine and Health Sciences
Mice
mRNA
Paraoxonase
Paraoxonase 1
Physiological aspects
PPAR gamma - metabolism
Protein folding
Research and Analysis Methods
Signal Transduction
Studies
Transfection
Transport
Up-Regulation
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Description
Summary:This study was aimed to investigate the effect of human PON1 overexpression in mice on cholesterol efflux and reverse cholesterol transport. PON1 overexpression in PON1-Tg mice induced a significant 3-fold (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0173385