Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children

The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with l...

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Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0174691-e0174691
Main Authors: Yao, Tsung-Chieh, Tsai, Hui-Ju, Chang, Su-Wei, Chung, Ren-Hua, Hsu, Jing-Ya, Tsai, Ming-Han, Liao, Sui-Ling, Hua, Man-Chin, Lai, Shen-Hao, Chen, Li-Chen, Yeh, Kuo-Wei, Tseng, Yu-Lun, Lin, Wan-Chen, Chang, Su-Ching, Huang, Jing-Long
Format: Article
Language:English
Subjects:
Adolescent
Air flow
Analysis
Asthma
Atopy
Bioinformatics
Biology and Life Sciences
Body mass
Body Mass Index
Body size
Body weight
Child
Child, Preschool
Children
Exhalation - physiology
Female
Forced Expiratory Volume
Health aspects
Health sciences
Hospitals
Humans
Hypersensitivity, Immediate - complications
Hypersensitivity, Immediate - physiopathology
Immunology
Lung - physiopathology
Lungs
Male
Maximal Midexpiratory Flow Rate
Medical research
Medicine
Medicine and Health Sciences
Mortality
Nitric oxide
Nitric Oxide - physiology
Obesity
Obesity - complications
Obesity - pathology
Obesity - physiopathology
Overweight
Parameter modification
Peak Expiratory Flow Rate
Pediatrics
People and Places
Physicians
Population
Pulmonary Ventilation
Respiratory diseases
Respiratory function
Respiratory Function Tests
Rheumatology
Vital Capacity
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Summary:The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy. We investigated the effect of excess weight on lung function and FeNO in a population sample of 1,717 children aged 5 to 18 years and explored the potential modifying effect of atopy. There were positive associations of body mass index (BMI) z-score with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) (all P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0174691