A novel multifunctional peptide oligomer of bacitracin with possible bioindustrial and therapeutic applications from a Korean food-source Bacillus strain

CSP32 has stable characteristics and may find bio-industrial and therapeutic applications.

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0176971-e0176971
Main Authors: Choi, Yun Hee, Cho, Seung Sik, Simkhada, Jaya Ram, Rahman, Md Saifur, Choi, Yoon Seok, Kim, Chun Sung, Yoo, Jin Cheol
Format: Article
Language:English
Subjects:
Acne
Amino acids
Analytical methods
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-inflammatory agents
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antibiotic resistance
Antibiotics
Antimicrobial activity
Bacillus - chemistry
Bacitracin
Bacitracin - analogs & derivatives
Bacitracin - pharmacology
Bacteria
Biodegradation
Biology and Life Sciences
Carbon
Causes of
Clostridium difficile - drug effects
Cyclooxygenase-2
Cytokines
Cytokines - immunology
Degradation
Drug resistance
Enterocolitis, Pseudomembranous - drug therapy
Enzyme-linked immunosorbent assay
Food
Food sources
Gram-Positive Bacterial Infections - drug therapy
Health aspects
Humans
Inflammation
Interleukin 1
Interleukin 6
Kimchi
Kinases
Laboratories
Lipopolysaccharides
Macrophages
Macrophages - drug effects
Macrophages - immunology
Mass spectrometry
Mass spectroscopy
Medicine and Health Sciences
Methicillin
Methicillin-Resistant Staphylococcus aureus - drug effects
Mice
Microorganisms
Molecular weight
Multidrug resistance
NF-κB protein
Nitric oxide
Nitric-oxide synthase
Nonsteroidal anti-inflammatory drugs
Oligomers
Pathogens
Penicillin
Peptides
Pharmacy
Phosphorylation
Physiological aspects
Polymerase chain reaction
Propionibacterium acnes - drug effects
RAW 264.7 Cells
Research and Analysis Methods
Researchers
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Translocation
Tumor necrosis factor-TNF
Vancomycin
Western blotting
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Description
Summary:CSP32 has stable characteristics and may find bio-industrial and therapeutic applications.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0176971