Leptin-adiponectin imbalance as a marker of metabolic syndrome among Chinese children and adolescents: The BCAMS study

Leptin and adiponectin have opposite effects on subclinical inflammation and insulin resistance, both involved in the development of metabolic syndrome (MS). We aimed to investigate whether leptin/adiponectin ratio (L/A), as a marker of these two adipokines imbalance, may improve diagnosis of MS in...

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Bibliographic Details
Published in:PloS one 2017-10, Vol.12 (10), p.e0186222-e0186222
Main Authors: Li, Ge, Xu, Linxin, Zhao, Yanglu, Li, Lujiao, Fu, Junling, Zhang, Qian, Li, Naishi, Xiao, Xinhua, Li, Changhong, Mi, Jie, Gao, Shan, Li, Ming
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - metabolism
Adolescent
Adolescents
Analysis
Asian Continental Ancestry Group
Beijing
Bioindicators
Biology and Life Sciences
Biomarkers
Biomarkers - metabolism
Cardiovascular disease
Care and treatment
Child
Child, Preschool
Children
Confidence Intervals
Correlation analysis
Development and progression
Diabetes
Diagnosis
Diagnostic systems
Endocrinology
Enzyme-linked immunosorbent assay
Epidemiology
Exercise
Families & family life
Family planning
Female
Gender
Girls
Glucose
Health screening
Hospitals
Humans
Hypertension
Insulin
Insulin resistance
Laboratories
Leptin
Leptin - metabolism
Longitudinal studies
Male
Medicine and Health Sciences
Metabolic diseases
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - diagnosis
Metabolic Syndrome - metabolism
Obesity
Odds Ratio
Pediatrics
Puberty
Reclassification
Teenagers
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Summary:Leptin and adiponectin have opposite effects on subclinical inflammation and insulin resistance, both involved in the development of metabolic syndrome (MS). We aimed to investigate whether leptin/adiponectin ratio (L/A), as a marker of these two adipokines imbalance, may improve diagnosis of MS in children and adolescents, and determined its cut-off value in the diagnosis of MS. A total of 3,428 subjects aged 6-18 years were selected from Beijing Child and Adolescent Metabolic Syndrome study. Adipokine leptin and adiponectin were measured using enzyme-linked immunosorbent assay. Odds ratio of MS per 1 z-score of adipokine was examined using logistic regression. Diagnosis accuracy was assessed using c-statistics (AUC) and net reclassification index. The levels of leptin and L/A increased with number of positive MS components, while the levels of adiponectin declined in both boys and girls (all P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186222