The microbiome and the hallmarks of cancer

Colibactin-producing (pks+) Escherichia coli induce a senescence-associated secretory phenotype (SASP) in which senescent cells secrete growth factors that stimulate epithelial proliferation and enhance tumor growth [5]. [...]microbial-induced cellular senescence and bystander proliferation provide...

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Bibliographic Details
Published in:PLoS pathogens 2017-09, Vol.13 (9), p.e1006480-e1006480
Main Authors: Fulbright, Laura E, Ellermann, Melissa, Arthur, Janelle C
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteroides fragilis
Biology and Life Sciences
Cancer
Colorectal cancer
Crosstalk
Damage patterns
Development and progression
Disease
E coli
Escherichia coli
Fusobacterium nucleatum
Growth factors
Humans
Immunology
Inflammation
Lipopolysaccharides
Medical research
Medicine and Health Sciences
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Neoplasms - microbiology
Pearls
Physiological aspects
Physiology
Receptors
Research and Analysis Methods
Rodents
Science
Senescence
Tumorigenesis
Tumors
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Summary:Colibactin-producing (pks+) Escherichia coli induce a senescence-associated secretory phenotype (SASP) in which senescent cells secrete growth factors that stimulate epithelial proliferation and enhance tumor growth [5]. [...]microbial-induced cellular senescence and bystander proliferation provide additional mechanisms by which malignancy can arise from host-microbial interactions. [...]in the context of infection, microbial products such as lipopolysaccharide engage with Toll-like receptors to promote angiogenesis, an effect that is augmented by damage-associated molecular patterns that may also be present within the tumor microenvironment [8]. [...]the earliest observations linking the microbiota with the hallmarks of cancer have primarily focused on gastric cancers and CRC. [...]the cancer microenvironment itself can enhance the procarcinogenic activities of the microbiota [23], which further demonstrates the importance of the crosstalk between host and microbe in modulating cancer progression.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006480