Alcoholic liver disease confers a worse prognosis than HCV infection and non-alcoholic fatty liver disease among patients with cirrhosis: An observational study

Cirrhosis is a heterogeneous clinical condition that includes patients at wide-ranging stages of severity. The role of the underlying liver disease on patient prognosis remains unclear. To assess the impact of the underlying liver disease on the occurrence of hepatocellular carcinoma (HCC) and death...

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Bibliographic Details
Published in:PloS one 2017-10, Vol.12 (10), p.e0186715-e0186715
Main Authors: Marot, Astrid, Henrion, Jean, Knebel, Jean-François, Moreno, Christophe, Deltenre, Pierre
Format: Article
Language:English
Subjects:
Aged
Alcohol use
Alcoholic beverages
Alcoholic liver diseases
Alcoholism
Biology and life sciences
Carcinoma, Hepatocellular - complications
Cause of Death
Chronic infection
Cirrhosis
Complications and side effects
Consent
Development and progression
Epidemiology
Eradication
Fatty liver
Female
Gastroenterology
Health aspects
Hepatitis
Hepatitis C
Hepatitis C - complications
Hepatitis C - pathology
Hepatocellular carcinoma
Hepatology
Humans
Incidence
Infections
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis, Alcoholic - complications
Liver Cirrhosis, Alcoholic - pathology
Liver diseases
Liver Diseases, Alcoholic - complications
Liver Diseases, Alcoholic - pathology
Liver Neoplasms - complications
Liver Transplantation
Male
Medical prognosis
Medicine and Health Sciences
Middle Aged
Mortality
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - pathology
Observational studies
Patients
Prognosis
Risk factors
Studies
Surveillance
Viruses
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Summary:Cirrhosis is a heterogeneous clinical condition that includes patients at wide-ranging stages of severity. The role of the underlying liver disease on patient prognosis remains unclear. To assess the impact of the underlying liver disease on the occurrence of hepatocellular carcinoma (HCC) and death. Data related to the occurrence of HCC and death were collected during a 21-year period among patients with cirrhosis related to alcoholic liver disease (ALD) (n = 529), chronic hepatitis C virus (HCV) infection (n = 145) or non-alcoholic fatty liver disease (NAFLD) (n = 78). At inclusion, ALD patients were younger than HCV and NAFLD patients (56 vs. 67 vs. 63 years; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186715