Reappraisal of Leishmanin Skin Test (LST) in the management of American Cutaneous Leishmaniasis: A retrospective analysis from a reference center in Argentina

Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diag...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2017-10, Vol.11 (10), p.e0005980-e0005980
Main Authors: Krolewiecki, Alejandro Javier, Almazan, Maria Cristina, Quipildor, Marcelo, Juarez, Marisa, Gil, Jose Fernando, Espinosa, Marco, Canabire, Maria, Cajal, Silvana Pamela
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age groups
Amastigotes
Analysis
Antigens
Antigens, Protozoan - immunology
Argentina - epidemiology
Biology and Life Sciences
Care and treatment
Child
Child, Preschool
Correlation analysis
Cutaneous leishmaniasis
Demographics
Diagnosis
Diagnostic systems
Disease Management
Endemic species
Female
Humans
Hypersensitivity
Hypersensitivity, Delayed
Identification
Infant
Infant, Newborn
Leishmania
Leishmania braziliensis - immunology
Leishmania braziliensis - isolation & purification
Leishmaniasis, Cutaneous - diagnosis
Leishmaniasis, Cutaneous - epidemiology
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - parasitology
Leishmanin
Lesions
Male
Medicine and Health Sciences
Middle Aged
Mucosa
Parasites
Parasitic diseases
People and places
Protocols
Ratios
Retrospective Studies
Skin
Skin - immunology
Skin - parasitology
Skin - pathology
Skin diseases
Skin Tests
Smear
Standardization
Supervision
Tegumentary leishmaniasis
Tropical diseases
Uses
Vector-borne diseases
Vectors (Biology)
Young Adult
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Description
Summary:Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diagnosis, based on delayed type hypersensitivity responses to Leishmania antigens injected intradermally, used in endemic areas as a complement to diagnosis. A retrospective analysis of individuals evaluated for their first episode of tegumentary leishmaniasis at a reference center in Argentina during the period 2006-2015 was performed, with the goal of assessing its usefulness as a support tool in the diagnosis of leishmaniasis. Demographic, clinical and diagnostic work-up were analyzed in individuals with clinically compatible lesions, lesion`s smear and LST. A total of 733 cases that met the case definition were included in the analysis; 678 (93%) localized cutaneous cases, 50 (7%) with mucosal involvement and 5 (
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0005980