A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study

To determine comparative fracture risk in HIV patients compared with uninfected controls. A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups. Hospital Outpatients. 222 HIV infected patients and an equal number of age-matched con...

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Bibliographic Details
Published in:PloS one 2013, Vol.8 (10), p.e78048-e78048
Main Authors: Peters, Barry S, Perry, Melissa, Wierzbicki, Anthony S, Wolber, Lisa E, Blake, Glen M, Patel, Nishma, Hoile, Richard, Duncan, Alastair, Kulasegaram, Ranjababu, Williams, Frances M K
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biocompatibility
Biomedical materials
Body mass
Body mass index
Body size
Bone mineral density
Cardiovascular diseases
Chronic illnesses
Cross-Sectional Studies
Diabetes mellitus
Female
Fractures
Fractures, Bone - epidemiology
Fractures, Bone - etiology
Fragility
Health risks
Hip
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Male
Middle Aged
Osteoporosis
Parathyroid hormone
Patients
Randomization
Risk analysis
Risk assessment
Risk factors
Risk management
Spine
Surveys and Questionnaires
Vitamin D
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Summary:To determine comparative fracture risk in HIV patients compared with uninfected controls. A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups. Hospital Outpatients. 222 HIV infected patients and an equal number of age-matched controls. Fracture risk factors were assessed and biochemical, endocrine and bone markers measured. BMD was assessed at hip and spine. 10-year fracture probability (FRAX) and remaining lifetime fracture probability (RFLP) were calculated. BMD, and history of fractures. Reported fractures occurred more frequently in HIV than controls, (45 vs. 16; 20.3 vs. 7%; OR=3.27; p=0.0001), and unsurprisingly in this age range, non-fragility fractures in men substantially contributed to this increase. Osteoporosis was more prevalent in patients with HIV (17.6% vs. 3.6%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0078048