A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study

To determine comparative fracture risk in HIV patients compared with uninfected controls. A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups. Hospital Outpatients. 222 HIV infected patients and an equal number of age-matched con...

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Published in:PloS one 2013, Vol.8 (10), p.e78048-e78048
Main Authors: Peters, Barry S, Perry, Melissa, Wierzbicki, Anthony S, Wolber, Lisa E, Blake, Glen M, Patel, Nishma, Hoile, Richard, Duncan, Alastair, Kulasegaram, Ranjababu, Williams, Frances M K
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biocompatibility
Biomedical materials
Body mass
Body mass index
Body size
Bone mineral density
Cardiovascular diseases
Chronic illnesses
Cross-Sectional Studies
Diabetes mellitus
Female
Fractures
Fractures, Bone - epidemiology
Fractures, Bone - etiology
Fragility
Health risks
Hip
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Male
Middle Aged
Osteoporosis
Parathyroid hormone
Patients
Randomization
Risk analysis
Risk assessment
Risk factors
Risk management
Spine
Surveys and Questionnaires
Vitamin D
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cited_by cdi_FETCH-LOGICAL-c526t-ef556670d916aa9227313cd129df0524a55b97c5d254ef64291c7e33cea0ef043
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container_issue 10
container_start_page e78048
container_title PloS one
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creator Peters, Barry S
Perry, Melissa
Wierzbicki, Anthony S
Wolber, Lisa E
Blake, Glen M
Patel, Nishma
Hoile, Richard
Duncan, Alastair
Kulasegaram, Ranjababu
Williams, Frances M K
description To determine comparative fracture risk in HIV patients compared with uninfected controls. A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups. Hospital Outpatients. 222 HIV infected patients and an equal number of age-matched controls. Fracture risk factors were assessed and biochemical, endocrine and bone markers measured. BMD was assessed at hip and spine. 10-year fracture probability (FRAX) and remaining lifetime fracture probability (RFLP) were calculated. BMD, and history of fractures. Reported fractures occurred more frequently in HIV than controls, (45 vs. 16; 20.3 vs. 7%; OR=3.27; p=0.0001), and unsurprisingly in this age range, non-fragility fractures in men substantially contributed to this increase. Osteoporosis was more prevalent in patients with HIV (17.6% vs. 3.6%, p
doi_str_mv 10.1371/journal.pone.0078048
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A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups. Hospital Outpatients. 222 HIV infected patients and an equal number of age-matched controls. Fracture risk factors were assessed and biochemical, endocrine and bone markers measured. BMD was assessed at hip and spine. 10-year fracture probability (FRAX) and remaining lifetime fracture probability (RFLP) were calculated. BMD, and history of fractures. Reported fractures occurred more frequently in HIV than controls, (45 vs. 16; 20.3 vs. 7%; OR=3.27; p=0.0001), and unsurprisingly in this age range, non-fragility fractures in men substantially contributed to this increase. Osteoporosis was more prevalent in patients with HIV (17.6% vs. 3.6%, p&lt;0.0001). BMD was most reduced, and predicted fracture rates most increased, at the spine. Low BMD was associated with antiretroviral therapy (ART), low body mass index and PTH. 10-year FRAX risk was &lt;5% for all groups. RLFP was greater in patients with HIV (OR=1.22; p=0.003) and increased with ART (2.4 vs. 1.50; OR= 1.50; p=0.03). The increased fracture rate in HIV patients in our relatively youthful population is partly driven by fractures, including non-fragility fractures, in men. Nonetheless, these findings may herald a rise in osteoporotic fractures in HIV patients. 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subjects Acquired immune deficiency syndrome
Adult
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biocompatibility
Biomedical materials
Body mass
Body mass index
Body size
Bone mineral density
Cardiovascular diseases
Chronic illnesses
Cross-Sectional Studies
Diabetes mellitus
Female
Fractures
Fractures, Bone - epidemiology
Fractures, Bone - etiology
Fragility
Health risks
Hip
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Male
Middle Aged
Osteoporosis
Parathyroid hormone
Patients
Randomization
Risk analysis
Risk assessment
Risk factors
Risk management
Spine
Surveys and Questionnaires
Vitamin D
title A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study
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