Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats

Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neu...

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Bibliographic Details
Published in:PloS one 2017-12, Vol.12 (12), p.e0189492-e0189492
Main Authors: Barrand, Sanna, Crowley, Tamsyn M, Wood-Bradley, Ryan J, De Jong, Kirstie A, Armitage, James A
Format: Article
Language:English
Subjects:
Abnormalities
Animals
Animals, Newborn
Appetite
Biology and Life Sciences
Blood glucose
Body fat
Body length
Body weight
Brain
Circuits
Coding
Collagen
Collagen (type I)
Dams
Diet
Diet, High-Fat
DNA methylation
Dopamine
Dopamine transporter
Energy balance
Female
Food
Gene expression
Gene regulation
Gene sequencing
Genes
Genomes
Health aspects
High fat diet
Homeostasis
Hydroxylase
Hypothalamus
Hypothalamus - metabolism
Insulin
Insulin-like growth factor II
Insulin-like growth factors
Laboratory rats
Leptin
Medicine
Medicine and Health Sciences
Neonates
Neural coding
Neurons
Neuropeptides
Neurosciences
Newborn babies
Nutrition
Obesity
Offspring
Peptides
Phenotype
Pregnancy
Priming
Proteins
Rats
Rats, Sprague-Dawley
Research and analysis methods
Ribonucleic acid
RNA
Rodents
Stem cells
Transcription
Transcriptome
Tyrosine
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Summary:Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window. We explored the effects of maternal high fat diet consumption on hypothalamic gene expression in Sprague Dawley rat offspring at postnatal day 10. RNA-sequencing enabled discovery of differentially expressed genes between offspring of dams fed a high fat diet and offspring of control diet fed dams. Female high fat diet offspring displayed altered expression of 86 genes (adjusted P-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0189492