Poxviruses: Slipping and sliding through transcription and translation

[...]encoding their own translation system is something apparently beyond the coding capacity of even the largest viruses identified to date, the mimiviruses, which infect amoeba and fall into the same family of nucleocytoplasmic large DNA viruses (NCLDVs) as poxviruses. [...]these decoded lysines c...

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Bibliographic Details
Published in:PLoS pathogens 2017-11, Vol.13 (11), p.e1006634-e1006634
Main Author: Walsh, Derek
Format: Article
Language:English
Subjects:
Adenosine
Amoeba
Biology and life sciences
Deoxyribonucleic acid
DNA
Gene expression
Kinases
Leadership
Medicine and Health Sciences
Pearls
Phosphorylation
Proteins
Ribonucleic acid
RNA
RNA polymerase
Self sufficiency
Slippage
Smallpox
Stalling
Transcription
Translation systems
Vaccines
Viruses
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Summary:[...]encoding their own translation system is something apparently beyond the coding capacity of even the largest viruses identified to date, the mimiviruses, which infect amoeba and fall into the same family of nucleocytoplasmic large DNA viruses (NCLDVs) as poxviruses. [...]these decoded lysines cause ribosome stalling, signaling decay of the mRNA [5]. Modification of RACK1 by the viral B1 kinase contributes to the ability of polyA leaders to function in infected cells. eIF, eukaryotic initiation factor; m-7-GTP, 7-Methylguanosine-5’-triphosphate; RACK1, receptor for activated C kinase 1; UTR, untranslated region; VacV, vaccinia virus; vRNAP, viral RNA polymerase. https://doi.org/10.1371/journal.ppat.1006634.g001 Poxviruses and translational control The study of poxviruses was fundamental to the discovery of the cap and polyA tail that we now know to be present on most eukaryotic mRNAs. While some of their mysteries have begun to be solved, there is undoubtedly much more to learn about how these enigmatic elements function. [...]what might once have been seen as the random generation of odd leaders through “erroneous” slippage of the viral RNA polymerase is now clearly part of a well-orchestrated strategy to confer translational advantages to viral mRNAs.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006634