Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana

Individuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general popul...

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Bibliographic Details
Published in:PloS one 2018-01, Vol.13 (1), p.e0190347-e0190347
Main Authors: Benneh-Akwasi Kuma, Amma, Owusu-Ansah, Amma Twumwa, Ampomah, Mary Akua, Sey, Fredericka, Olayemi, Edeghonghon, Nouraie, Mehdi, Ofori-Acquah, Solomon Fiifi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aged
Aged, 80 and over
Anemia
Anemia, Sickle Cell - complications
Biology and Life Sciences
Blood
Blood pressure
Complications
Computer and Information Sciences
Female
Genetics
Genotypes
Ghana - epidemiology
Health care
Health sciences
Hematology
Historical account
Humans
Hypertension
Hypertension - complications
Hypertension - epidemiology
Kidneys
Laboratories
Male
Males
Medicine
Medicine and Health Sciences
Middle Aged
Mortality
Mutation
Patients
People and Places
Population
Prevalence
Pulmonary hypertension
Renal insufficiency
Sickle cell disease
Vascular diseases
Young Adult
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Summary:Individuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general population. This phenomenon is termed relative systemic hypertension (RSH) with a systolic blood pressure range of 120-139 mmHg, and diastolic blood pressure range of 70-89 mmHg. The significance of RSH lies in its association with renal insufficiency, pulmonary hypertension, stroke and propensity to progress to systemic hypertension. We conducted a retrospective chart review of 1,000 adults with sickle cell disease at the Ghana Institute of Clinical Genetics, to determine the prevalence of RSH in sickle cell disease in Ghana and associated complications. We found a high prevalence of RSH and hypertension with a relatively low frequency of renal insufficiency. Pulse pressure, a predictor of mortality, was higher in males of all ages. We anticipate that providing an estimate of the burden of RSH will heighten its recognition and clinical management among health care providers.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0190347