Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases

In inflammatory bowel disease (IBD), immune activation with increased circulating TNF-α is linked to the intensity of gastrointestinal symptoms and depression or anxiety. A central feature of depression is cognitive biases linked to negative attributions about self, the world and the future. We aime...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0193542-e0193542
Main Authors: Gray, Marcus A, Chao, Che-Yung, Staudacher, Heidi M, Kolosky, Natasha A, Talley, Nicholas J, Holtmann, Gerald
Format: Article
Language:English
Subjects:
Amygdala
Anxiety
Behavioral sciences
Biology and Life Sciences
Brain
Brain mapping
Brain research
Cognitive ability
Crohn's disease
Functional magnetic resonance imaging
Gastroenterology
Gastrointestinal symptoms
Hepatology
Hospitals
Immune response
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Infliximab
Intestine
Irritable bowel syndrome
Magnetic resonance
Magnetic resonance imaging
Medicine and Health Sciences
Mental depression
Monoclonal antibodies
Neuroimaging
NMR
Nuclear magnetic resonance
Nutrients
Pain
Patients
Psychiatry
Ratings
Research and Analysis Methods
Sensory neurons
Social Sciences
Therapy
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:In inflammatory bowel disease (IBD), immune activation with increased circulating TNF-α is linked to the intensity of gastrointestinal symptoms and depression or anxiety. A central feature of depression is cognitive biases linked to negative attributions about self, the world and the future. We aimed to assess the effects of anti-TNFα therapy on the central processing of self-attribution biases and visceral afferent information in patients with Crohn's disease. We examined 9 patients with Crohn's disease (age 26.1±10.6. yrs, 5 female, 5 ileocolonic, 2 colonic and 2 ileal disease) during chronic anti-TNFα therapy (5 adalimumab, 4 infliximab). Patients were studied twice in randomized order before and after anti-TNFα administration. On each occasion patients underwent functional magnetic resonance imaging (fMRI) of the brain during a test of implicit attribution biases regarding sickness/health and undertook a standardized nutrient challenge. Following anti-TNFα treatment, ratings of 'fullness' following nutrient challenge reduced compared to pre-treatment ratings (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0193542