Epidemiology and outcomes of anaphylaxis-associated out-of-hospital cardiac arrest

Understanding the epidemiological characteristics of anaphylaxis-associated out-of-hospital cardiac arrest (OHCA) is the first step toward developing preventative strategies and optimizing care systems. We aimed to describe and compare epidemiological features and clinical outcomes among patients wi...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0194921-e0194921
Main Authors: Lee, Sun Young, Lee, Seung Chul, Shin, Sang Do, Song, Kyoung Jun, Ro, Young Sun, Park, Jeong Ho, Kong, So Yeon
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anaphylaxis
Anaphylaxis - complications
Biology and Life Sciences
Cardiac arrest
Cardiopulmonary resuscitation
Causes of
Complications and side effects
CPR
Discharge
Diurnal
Earth Sciences
Electrocardiography
Emergency medical care
Emergency Medical Services
Emergency services
Epidemiology
Female
Health services
Heart
Heart diseases
Humans
Identification methods
Incidence
Logistic Models
Male
Medical research
Medicine and Health Sciences
Middle Aged
Odds Ratio
Out-of-Hospital Cardiac Arrest - epidemiology
Out-of-Hospital Cardiac Arrest - etiology
Out-of-Hospital Cardiac Arrest - mortality
Patient Discharge
Patient outcomes
Patients
People and Places
Prevention
Regression analysis
Risk factors
Seasonal variability
Seasonal variations
Seasons
Studies
Summer
Survival
Survival Rate
Temporal variability
Time Factors
Variability
Young Adult
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Summary:Understanding the epidemiological characteristics of anaphylaxis-associated out-of-hospital cardiac arrest (OHCA) is the first step toward developing preventative strategies and optimizing care systems. We aimed to describe and compare epidemiological features and clinical outcomes among patients with anaphylaxis-associated OHCAs according to causative agent groups. We identified emergency medical service (EMS)-treated anaphylaxis-associated OHCA patients from a nationwide OHCA registry between 2008 and 2015. We compared epidemiological characteristics and outcomes according to causal agents (a natural agents group and an iatrogenic agents group) and evaluated temporal variability in incidence. Multivariate logistic regression analysis was performed to compare survival to discharge between causative agent groups. During the study period (8 years), the total number of anaphylaxis-associated OHCAs was 233. A total of 224 eligible cases were included in the analysis. There were 192 patients (85.6%) in the natural agents group and 32 patients (14.3%) in the iatrogenic agents group. There was significant diurnal and seasonal variability in the frequency of anaphylaxis-associated OHCAs (p values
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0194921