Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study

• Published in: PloS one 2018-04, Vol.13 (4), p.e0195700
• Main Authors: Wang, Yuanliu, Li, Honghui, Zheng, Min, Wu, Yubi, Zeng, Ting, Fu, Jinjian, Zeng, Dingyuan
• Format: Article
• Language: English
• Subjects: Adult; Biology and Life Sciences; Birth weight; Calcium; Care and treatment; China; Cohort analysis; Cord blood; Diabetes mellitus; Female; Fetal Blood - metabolism; Gestational diabetes; Health aspects; Health risk assessment; Health risks; Humans; Infant, Low Birth Weight - blood; Infant, Newborn; Infant, Small for Gestational Age - blood; Infants; Logistic Models; Low birth weight; Male; Medicine and Health Sciences; Minority & ethnic groups; Neonates; Newborn babies; Newborn infants; Nutrient deficiency; Population studies; Pregnancy; Pregnancy Complications - blood; Pregnancy Complications - epidemiology; Pregnant women; Prevalence; Prospective Studies; Research and Analysis Methods; Risk; Risk Factors; Risk reduction; Small for gestational age; Supplements; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - epidemiology; Vitamin deficiency; Womens health; Wu, Ting
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0195700

Although vitamin D (vitD) deficiency is a common problem in pregnant women, in China, few studies have focused on the relationship between maternal vitD deficiency throughout the three trimesters and subsequent neonatal outcomes in China. Between 2015 and 2016, maternal serum and neonate cord blood samples were collected from 1978 mother-neonate pairs from Liuzhou city. The mean concentrations of 25-hydroxy vitD (25(OH)D) were 16.17±6.27 and 15.23±5.43 ng/ml in the mother and neonate groups, respectively, and the prevalence values of vitD deficiency in the two groups were 78.18% and 83.27%, respectively. Logistic regression showed that maternal vitD deficiency independently increased the risk of gestational diabetes mellitus (GDM) (adjust OR, aOR 1.08; P = 0.026). A relatively lower risk of vitD deficiency was observed in the third trimester than in the first and second trimester (aOR 0.80; P = 0.004). VitD-calcium cosupplementation during pregnancy improves the vitD deficiency in both the maternal and neonatal groups (aOR 0.56, 0.66; P