Antagonist muscle activity during reactive balance responses is elevated in Parkinson's disease and in balance impairment

Abnormal antagonist leg muscle activity could indicate increased muscle co-contraction and clarify mechanisms of balance impairments in Parkinson's disease (PD). Prior studies in carefully selected patients showed PD patients demonstrate earlier, longer, and larger antagonist muscle activation...

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Bibliographic Details
Published in:PloS one 2019-01, Vol.14 (1), p.e0211137-e0211137
Main Authors: Lang, Kimberly C, Hackney, Madeleine E, Ting, Lena H, McKay, J Lucas
Format: Article
Language:English
Subjects:
Activation
Age
Aged
Analysis
Balance
Biology and Life Sciences
Biomedical engineering
Care and treatment
Contraction
Cross-Sectional Studies
Electromyography
Exercise
Female
Gait
Genetic aspects
Genotype & phenotype
Health aspects
Humans
Impairment
Leg
Male
Medicine
Medicine and Health Sciences
Middle Aged
Modulation
Movement disorders
Muscle contraction
Muscle function
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Muscles
Neurodegenerative diseases
Older people
Outcome and process assessment (Medical care)
Parkinson disease
Parkinson Disease - pathology
Parkinson Disease - physiopathology
Parkinson's disease
Patients
Phenotypes
Postural Balance
Posture
Questionnaires
Rehabilitation
Research and Analysis Methods
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Description
Summary:Abnormal antagonist leg muscle activity could indicate increased muscle co-contraction and clarify mechanisms of balance impairments in Parkinson's disease (PD). Prior studies in carefully selected patients showed PD patients demonstrate earlier, longer, and larger antagonist muscle activation during reactive balance responses to perturbations. Here, we tested whether antagonist leg muscle activity was abnormal in a group of PD patients who were not selected for phenotype and most of whom had volunteered for exercise-based rehabilitation. We compared antagonist activation during reactive balance responses to multidirectional support-surface translation perturbations in 31 patients with mild-moderate PD (age 68±9; H&Y 1-3; UPDRS-III 32±10) and 13 matched individuals (age 65±9). We quantified modulation of muscle activity (i.e., the ability to activate and inhibit muscles appropriately according to the perturbation direction) using modulation indices (MI) derived from minimum and maximum EMG activation levels observed across perturbation directions. Antagonist leg muscle activity was abnormal in unselected PD patients compared to controls. Linear mixed models identified significant associations between impaired modulation and PD (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0211137