Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload

Humans have a lower risk of death from myocardial infarction (MI) living at low elevations (5000 m, and intermittent hypobaric hypoxia post-MI can reduce MI size in rodents, and it is believed that hypoxia is the key stimulus. To explore mechanisms beyond hypoxia we studied whether altitude simulati...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-05, Vol.14 (5), p.e0215814-e0215814
Main Authors: Shahid, Anmol, Patel, Vaibhav B, Morton, Jude S, Stenson, Trevor H, Davidge, Sandra T, Oudit, Gavin Y, McMurtry, Michael S
Format: Article
Language:English
Subjects:
Altitude
Altitude effects
Altitude simulation
Animals
Atmospheric pressure
Biology and Life Sciences
Blood pressure
Cardiac output
Cardiovascular disease
Catheterization
Cerebral infarction
Consciousness
Coronary vessels
Gene Expression Regulation
Gynecology
Heart attacks
Heart failure
Heart rate
Hemodynamics
Hypoxia
Hypoxia-inducible factor 1
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Ischemia
Low altitude
Medicine
Medicine and Health Sciences
Mice
Mice, Inbred C57BL
Mortality
Mouse devices
Myocardial infarction
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Obstetrics
Ostomy
Oxygen
Physiology
Polyethylene
Recording
Rodent control
Rodents
Sea level
Simulation
Stroke
Stroke Volume
Vascularization
Ventricle
Ventricular Function, Left
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Humans have a lower risk of death from myocardial infarction (MI) living at low elevations (5000 m, and intermittent hypobaric hypoxia post-MI can reduce MI size in rodents, and it is believed that hypoxia is the key stimulus. To explore mechanisms beyond hypoxia we studied whether altitude simulation
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0215814