Learning from the past: A reverberation of past errors in the cerebellar climbing fiber signal

The cerebellum allows us to rapidly adjust motor behavior to the needs of the situation. It is commonly assumed that cerebellum-based motor learning is guided by the difference between the desired and the actual behavior, i.e., by error information. Not only immediate but also future behavior will b...

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Bibliographic Details
Published in:PLoS biology 2018-08, Vol.16 (8), p.e2004344-e2004344
Main Authors: Junker, Marc, Endres, Dominik, Sun, Zong Peng, Dicke, Peter W, Giese, Martin, Thier, Peter
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Adaptation
Animals
Axons - physiology
Behavior
Biology and Life Sciences
Brain research
Cellular signal transduction
Cerebellum
Cerebellum - anatomy & histology
Cerebellum - cytology
Cerebellum - physiology
Climbing
Electrodes, Implanted
Engineering and Technology
Fibers
Information theory
Learning
Learning - physiology
Macaca mulatta
Male
Medicine and Health Sciences
Models, Neurological
Monkeys
Motor skill learning
Neurofibrils
Neurological research
Neurology
Neurosciences
Pattern Recognition, Visual - physiology
Physical Sciences
Physiological aspects
Psychomotor Performance - physiology
Purkinje cells
Purkinje Cells - cytology
Purkinje Cells - physiology
Saccades - physiology
Signal transduction
Social Sciences
Software
Stereotaxic Techniques
Synapses
Synapses - physiology
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Summary:The cerebellum allows us to rapidly adjust motor behavior to the needs of the situation. It is commonly assumed that cerebellum-based motor learning is guided by the difference between the desired and the actual behavior, i.e., by error information. Not only immediate but also future behavior will benefit from an error because it induces lasting changes of parallel fiber synapses on Purkinje cells (PCs), whose output mediates the behavioral adjustments. Olivary climbing fibers, likewise connecting with PCs, are thought to transport information on instant errors needed for the synaptic modification yet not to contribute to error memory. Here, we report work on monkeys tested in a saccadic learning paradigm that challenges this concept. We demonstrate not only a clear complex spikes (CS) signature of the error at the time of its occurrence but also a reverberation of this signature much later, before a new manifestation of the behavior, suitable to improve it.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.2004344