Microbiome evolution during host aging

Experiments in mice colonized with Escherichia coli have shown clonal interference and parallel phenotypic evolution in the gut, occurring from the emergence of several adaptive genetic variants that reach intermediate frequencies, rather than reaching fixation (i.e., maximum frequency), within indi...

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Bibliographic Details
Published in:PLoS pathogens 2019-07, Vol.15 (7), p.e1007727-e1007727
Main Authors: Aleman, Francisco Daniel Davila, Valenzano, Dario Riccardo
Format: Article
Language:English
Subjects:
Age
Aging
Aging (Biology)
Aging - physiology
Analysis
Animals
Bacteria
Bacterial infections
Biodiversity
Biological Evolution
Biology
Biology and Life Sciences
Cancer
Computer and Information Sciences
Disease
E coli
Evolution & development
Fitness
Gastrointestinal Microbiome - genetics
Gastrointestinal Microbiome - physiology
Genetic diversity
Genetic variance
Host Microbial Interactions - physiology
Host-bacteria relationships
Humans
Inflammation
Laboratories
Life span
Medicine and Health Sciences
Metabolism
Metabolites
Microbial Consortia - genetics
Microbial Consortia - physiology
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microbiota - genetics
Microbiota - physiology
Microorganisms
Mitochondria
Mutation
Nematodes
Pearls
Polysaccharides
Protein folding
Reproductive fitness
Secretion
Species diversity
Strains (organisms)
Taxonomy
Time Factors
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Description
Summary:Experiments in mice colonized with Escherichia coli have shown clonal interference and parallel phenotypic evolution in the gut, occurring from the emergence of several adaptive genetic variants that reach intermediate frequencies, rather than reaching fixation (i.e., maximum frequency), within individual bacterial species. Screening a library of mutant E. coli for effects on nematode worm survival and aging has shown that a set of mutant strains beneficially affect host mitochondrial unfolded protein responses via the secretion of the polysaccharide colanic acid, resulting in increased worm life span [47]. [...]while experimental nematodes are generally fed a specific E. coli strain (OP50) [48], complex microbiota likely mask the impact on host fitness of individual bacterial strains emerging within specific bacterial species. Since during aging and frailty the overall microbial taxonomic diversity declines, it may indeed become more likely for new strains within dominant taxa to sweep to high frequency and affect the host.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1007727