Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study

The debate whether "asymptomatic hyperuricemia" should be treated is still ongoing. The objective of this cross-sectional study was to analyze whether hyperuricema in the elderly is associated with joint pain. Participants in the population-based AGES-Reykjavik Study (males 2195, females 2...

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Bibliographic Details
Published in:PloS one 2019-08, Vol.14 (8), p.e0221474
Main Authors: Jonsson, Helgi, Aspelund, Thor, Eiriksdottir, Gudny, Harris, Tamara B, Launer, Lenore J, Gudnason, Vilmundur
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Area Under Curve
Arthralgia
Arthralgia - blood
Arthralgia - etiology
Arthritis
Biology and Life Sciences
Biomedical materials
Causes of
Complications and side effects
Cross-Sectional Studies
Demographic aspects
Elderly women
Female
Females
Geriatrics
Hand
Hand injuries
Hand Joints - pathology
Health aspects
Heart
Humans
Hyperuricemia
Hyperuricemia - blood
Hyperuricemia - complications
Iceland
Joint diseases
Laboratories
Males
Medicine and Health Sciences
Metabolism
Older people
Osteoarthritis
Osteoarthritis - etiology
Pain
Pain management
People and Places
Physical Sciences
Population
Population studies
Purines
Questionnaires
Rheumatism
Rheumatology
Risk analysis
Risk factors
Studies
Type 2 diabetes
Uric acid
Uric Acid - blood
Women
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Summary:The debate whether "asymptomatic hyperuricemia" should be treated is still ongoing. The objective of this cross-sectional study was to analyze whether hyperuricema in the elderly is associated with joint pain. Participants in the population-based AGES-Reykjavik Study (males 2195, females 2975, mean age 76(6)) answered standardized questions about joint pain. In addition they recorded intermittent hand joint pain by marking a diagram of the hand. In males, no association was found between hyperuricemia and pain. Females however, showed a positive association between hyperuricemia and joint pain at many sites. After adjustment for age, BMI and hand osteoarthritis however, only intermittent hand joint pain (OR 1.30(1.07-1.58), p = 0.008) and intermittent pain in ≥10 hand joints (OR 1.75(1.32-2.31), p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221474