Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21

TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is the natural agonist for the complement 3a receptor 1 (C3aR1) ha...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-08, Vol.14 (8), p.e0221517-e0221517
Main Authors: Lisci, Carlo, Lewis, Jo E, Daniel, Zoe C T R, Stevenson, Tyler J, Monnier, Chloe, Marshall, Hayley J, Fowler, Maxine, Ebling, Francis J P, Ferri, Gian-Luca, Cocco, Cristina, Jethwa, Preeti H
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissue (brown)
Adiposity - drug effects
Animals
Annual variations
Appetite
Biology and Life Sciences
Biomarkers
Body weight
Brain - metabolism
Carbon Dioxide - metabolism
Cricetinae
EDTA
Energy balance
Energy expenditure
Energy Metabolism
Female
Food
Food intake
Gene Expression
Genes
Genomes
Hamsters
Hormones
Hypothalamus
Intracerebroventricular administration
Laboratory animals
Life sciences
Medical research
Medical schools
Medicine and Health Sciences
Messenger RNA
Metabolism
mRNA
Neuropeptides
Neuropeptides - pharmacology
Obesity
Oxygen - metabolism
Peptide Fragments - pharmacology
Peptides
Phenotypes
Photoperiod
Photoperiods
Proteins
Receptors, Complement - metabolism
Research and Analysis Methods
RNA
Rodents
Seasonal variations
Thyroid gland
Uncoupling protein 1
Weight reduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is the natural agonist for the complement 3a receptor 1 (C3aR1) has revived interest in this peptide as a potential drug target for obesity. We have investigated its function in Siberian hamsters (Phodopus sungorus), a rodent that displays natural seasonal changes in body weight and adiposity as an adaptation to survive winter. We have previously shown that intracerebroventricular administration of TLQP-21 reduced food intake and body weight in hamsters in their long-day fat state. The aim of our current study was to determine the systemic actions of TLQP-21 on food intake, energy expenditure and body weight, and to establish whether adiposity affected these responses. Peripheral infusion of TLQP-21 (1mg/kg/day for 7 days) in lean hamsters exposed to short photoperiods (SP) reduced cumulative food intake in the home cage (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0221517