Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study

Increased serum levels of C-reactive protein (CRP), an important component of the innate immune response, are associated with increased risk of cardiovascular disease (CVD). Multiple single nucleotide polymorphisms (SNP) have been identified which are associated with CRP levels, and Mendelian random...

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Bibliographic Details
Published in:PloS one 2019-10, Vol.14 (10), p.e0223574
Main Authors: Best, Lyle G, Balakrishnan, Poojitha, Cole, Shelley A, Haack, Karin, Kocarnik, Jonathan M, Pankratz, Nathan, Anderson, Matthew Z, Franceschini, Nora, Howard, Barbara V, Lee, Elisa T, North, Kari E, Umans, Jason G, Yracheta, Joseph M, Navas-Acien, Ana, Voruganti, V Saroja
Format: Article
Language:English
Subjects:
African Americans
Alleles
Biology and Life Sciences
Biomarkers - blood
Biomedical research
C-reactive protein
C-Reactive Protein - genetics
Cancer
Cardiovascular diseases
Chromosomes
Colon
Colon cancer
Diabetes
Environmental health
Family studies
Female
Gene loci
Genetic analysis
Genetic diversity
Genetic Linkage
Genetic markers
Genetic Predisposition to Disease
Genetic variance
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Genomes
Genomics
Genotype
Genotypes
Health risks
Health sciences
Heart diseases
Heritability
Humans
Immune response
Indians, North American - genetics
Influence
Innate immunity
Male
Markers
Medical research
Medicine and Health Sciences
Metabolism
Microsatellites
Minority & ethnic groups
Native Americans
Nucleotides
Nutrition research
Obesity
Polymorphism, Single Nucleotide
Population genetics
Populations
Proteins
Public health
Serum levels
Single-nucleotide polymorphism
Studies
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Description
Summary:Increased serum levels of C-reactive protein (CRP), an important component of the innate immune response, are associated with increased risk of cardiovascular disease (CVD). Multiple single nucleotide polymorphisms (SNP) have been identified which are associated with CRP levels, and Mendelian randomization studies have shown a positive association between SNPs increasing CRP expression and risk of colon cancer (but thus far not CVD). The effects of individual genetic variants often interact with the genetic background of a population and hence we sought to resolve the genetic determinants of serum CRP in a number of American Indian populations. The Strong Heart Family Study (SHFS) has serum CRP measurements from 2428 tribal members, recruited as large families from three regions of the United States. Microsatellite markers and MetaboChip defined SNP genotypes were incorporated into variance components, decomposition-based linkage and association analyses. CRP levels exhibited significant heritability (h2 = 0.33 ± 0.05, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0223574