Decreased retinal thickness in patients with Alzheimer's disease is correlated with disease severity

The loss of retinal ganglion cells observed in Alzheimer's disease (AD) may be attributable to a neurodegeneration of the neuro-retinal structure. Amnestic mild cognitive impairment (aMCI) has been considered a prodromal stage of AD. We evaluated retinal thicknesses in patients with aMCI and AD...

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Bibliographic Details
Published in:PloS one 2019-11, Vol.14 (11), p.e0224180-e0224180
Main Authors: Kim, Jae-Il, Kang, Bong-Hui
Format: Article
Language:English
Subjects:
Advertising executives
Aged
Aged, 80 and over
Alzheimer Disease - complications
Alzheimer Disease - diagnosis
Alzheimer's disease
Biology and Life Sciences
Care and treatment
Cognitive ability
Cognitive Dysfunction - complications
Cognitive Dysfunction - diagnosis
Correlation
Cross-Sectional Studies
Dementia
Dementia disorders
Diabetic retinopathy
Dietary fiber
Evaluation
Female
Ganglion cysts
Glaucoma
Hospitals
Humans
Male
Medical diagnosis
Medicine and Health Sciences
Mental Status and Dementia Tests
Middle Aged
Neurodegeneration
Neurology
NMR
Nuclear magnetic resonance
Optical Coherence Tomography
Optics
Research and Analysis Methods
Retina
Retina - diagnostic imaging
Retina - pathology
Retinal Degeneration - diagnosis
Retinal Degeneration - etiology
Retinal Degeneration - pathology
Retinal ganglion cells
Severity of Illness Index
Studies
Systematic review
Thickness
Tomography
Tomography, Optical Coherence
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Summary:The loss of retinal ganglion cells observed in Alzheimer's disease (AD) may be attributable to a neurodegeneration of the neuro-retinal structure. Amnestic mild cognitive impairment (aMCI) has been considered a prodromal stage of AD. We evaluated retinal thicknesses in patients with aMCI and AD compared to healthy controls using spectral-domain optical coherence tomography (OCT) to investigate whether changes in retinal thickness are correlated with the clinical severity of dementia. Patients with aMCI (n = 14), mild to moderate AD (n = 7), severe AD (n = 9), and age-matched controls (n = 17) underwent neuro-ophthalmologic examinations. Global deterioration scale (GDS), clinical dementia rating (CDR), and mini-mental status examination (MMSE) were used to evaluate the clinical overall severity of dementia. The thicknesses of the peripapillary retinal nerve fiber layer (RNFL), total macula, and macular ganglion cell-inner plexiform layer (GC-IPL) were measured using Cirrus HD-OCT. The severe AD group had overall significantly thinner GC-IPL, total macula, and peripapillary RNFL compared to the controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0224180