Higher prevalence of splenic artery aneurysms in hereditary hemorrhagic telangiectasia: Vascular implications and risk factors

Splenic artery aneurysm (SAA) is a rare but potentially fatal condition. Rupture results in 25% mortality up to 75% in pregnant women with 95% fetal mortality. Brief reports suggest an increased risk of developing SAA in patients with HHT. We analyzed enhanced multidetector CT data in 186 HHT patien...

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Published in:PloS one 2020-01, Vol.15 (1), p.e0226681-e0226681
Main Authors: Sellier, Jacques, Karam, Carma, Beauchet, Alain, Dallongeville, Axel, Binsse, Stephen, Blivet, Sandra, Bourgault-Villada, Isabelle, Charron, Philippe, Chinet, Thierry, Eyries, Mélanie, Fagnou, Carole, Lesniak, Jérome, Lesur, Gilles, Lucas, Jérome, Nicod-Tran, Agnès, Ozanne, Augustin, Palmyre, Aurélien, Soubrier, Florent, El Hajjam, Mostafa, Lacombe, Pascal
Format: Article
Language:English
Subjects:
Adult
Aged
Aneurysm
Aneurysm - diagnostic imaging
Aneurysm - epidemiology
Aneurysm - etiology
Aneurysm - pathology
Aorta
Arteries
Biology and Life Sciences
Cardiovascular diseases
Case-Control Studies
Family medical history
Female
Fetuses
Follow-Up Studies
France - epidemiology
Gender
Genetics
Health aspects
Health risks
Hemorrhage
Hepatic artery
Hereditary hemorrhagic telangiectasia
Homogenization
Humans
Hypertension
Life Sciences
Liver
Male
Medicine and Health Sciences
Middle Aged
Mortality
Multidetector Computed Tomography
Multivariate analysis
Mutation
Pancreas
Pregnancy
Pregnant women
Prevalence
Prognosis
Pulmonary arteries
Research and Analysis Methods
Retrospective Studies
Risk analysis
Risk Factors
Santé publique et épidémiologie
Spleen
Splenic artery
Splenic Artery - pathology
Telangiectasia, Hereditary Hemorrhagic - complications
Telangiectasis
Vascular diseases
Vascular Diseases - diagnostic imaging
Vascular Diseases - epidemiology
Vascular Diseases - etiology
Vascular Diseases - pathology
Veins & arteries
Women
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Summary:Splenic artery aneurysm (SAA) is a rare but potentially fatal condition. Rupture results in 25% mortality up to 75% in pregnant women with 95% fetal mortality. Brief reports suggest an increased risk of developing SAA in patients with HHT. We analyzed enhanced multidetector CT data in 186 HHT patients matched (gender and ± 5 year old) with 186 controls. We screened for SAA and recorded diameter of splenic and hepatic arteries and hepatic, pancreatic and splenic parenchymal involvements. We determined by univariate and multivariate analysis, the relationship with age, sex, genetic status, cardiovascular risk factors (CVRF) and visceral involvement. SAA concerned 24.7% of HHT patients and 5.4% of controls, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0226681