Changes in inflammatory and vasoactive mediator profiles during valvular surgery with or without infective endocarditis: A case control pilot study

More than 50% of patients with infective endocarditis (IE) develop an indication for surgery. Despite its benefit, surgery is associated with a high incidence of multiple organ dysfunction syndrome (MODS) and mortality, which may be linked to increased release of inflammatory mediators during cardio...

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Bibliographic Details
Published in:PloS one 2020-02, Vol.15 (2), p.e0228286-e0228286
Main Authors: Diab, Mahmoud, Tasar, Raphael, Sponholz, Christoph, Lehmann, Thomas, Pletz, Mathias W, Bauer, Michael, Brunkhorst, Frank M, Doenst, Torsten
Format: Article
Language:English
Subjects:
Adrenomedullin
Age composition
Aged
Anesthesiology
Atrial natriuretic peptide
Biology and Life Sciences
Biomarkers
Cardiac patients
Cardiovascular disease
Case-Control Studies
Computer and Information Sciences
Coronary artery bypass
Critical care
Cytokines
Cytokines - blood
Data analysis
Data processing
Drug dosages
Endocarditis
Endocarditis - blood
Endocarditis - surgery
Female
Health aspects
Heart
Heart surgery
Heart valves
Heart Valves - surgery
Hospitals
Humans
IL-1β
Infective endocarditis
Inflammation
Inflammation - metabolism
Inflammation Mediators - blood
Inflammatory response
Interleukin 18
Interleukin 6
Male
Medical research
Medicine and Health Sciences
Middle Aged
Mortality
Multiple organ failure
Natriuretic peptides
Patients
Peptides
Pilot Projects
Plasma levels
Renal replacement therapy
Sample size
Sepsis
Software
Studies
Surgery
Time
Tumor necrosis factor
Tumor necrosis factor-TNF
Vasoactive agents
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Summary:More than 50% of patients with infective endocarditis (IE) develop an indication for surgery. Despite its benefit, surgery is associated with a high incidence of multiple organ dysfunction syndrome (MODS) and mortality, which may be linked to increased release of inflammatory mediators during cardiopulmonary bypass (CPB). We therefore assessed plasma cytokine profiles in patients undergoing valve surgery with or without IE. We performed a prospective case-control pilot study comparing patients undergoing cardiac valve surgery with or without IE. Plasma profiles of inflammatory mediators were measured at 7 defined time points and reported as median (interquartile). The degree of MODS was measured using sequential organ failure assessment (SOFA) score. Between May and December 2016 we included 40 patients (20 in each group). Both groups showed similar distribution of age and gender. Patients with IE had higher preoperative SOFA (6.9± 2.6 vs 3.8 ± 1.1, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0228286