Towards understanding the antagonistic activity of phytic acid against common foodborne bacterial pathogens using a general linear model

The increasing challenge of antibiotic resistance requires not only the discovery of new antibiotics, but also the development of new alternative approaches. Therefore, in the present study, we investigated for the first time the antibacterial potential of phytic acid (myo-inositol hexakisphosphate,...

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Bibliographic Details
Published in:PloS one 2020-04, Vol.15 (4), p.e0231397
Main Authors: Boukhris, Ines, Smaoui, Slim, Ennouri, Karim, Morjene, Nawres, Farhat-Khemakhem, Ameny, Blibech, Monia, Alghamdi, Othman A, Chouayekh, Hichem
Format: Article
Language:English
Subjects:
Acids
Acriflavine
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Biofilms
Biology and Life Sciences
Ceftazidime
Citric acid
Citric Acid - pharmacology
Disease
Esculin
Food industry
Food Microbiology
Food preservation
Food processing industry
Food safety
Foodborne pathogens
Gram-negative bacteria
Gram-positive bacteria
Inositol
Linear Models
Listeria
Listeria monocytogenes
Listeria monocytogenes - drug effects
Listeria monocytogenes - growth & development
Lithium
Lithium chloride
Lysine
Mannitol
Medicine and Health Sciences
Microbial Sensitivity Tests
Minimum inhibitory concentration
Pathogens
Physical Sciences
Phytic acid
Phytic Acid - pharmacology
Salmonella
Salmonella typhimurium - drug effects
Salmonella typhimurium - growth & development
Shelf life
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
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Summary:The increasing challenge of antibiotic resistance requires not only the discovery of new antibiotics, but also the development of new alternative approaches. Therefore, in the present study, we investigated for the first time the antibacterial potential of phytic acid (myo-inositol hexakisphosphate, IP6), a natural molecule that is 'generally recognized as safe' (FDA classification), against the proliferation of common foodborne bacterial pathogens such as Listeria monocytogenes, Staphylococcus aureus and Salmonella Typhimurium. Interestingly, compared to citric acid, IP6 was found to exhibit significantly greater inhibitory activity (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0231397