Clinical impact of diabetes mellitus on 2-year clinical outcomes following PCI with second-generation drug-eluting stents; Landmark analysis findings from patient registry: Pooled analysis of the Korean multicenter drug-eluting stent registry

Using patient-level data from two stent-specific, all-comer, prospective DES registries, we evaluated 1,913 patients who underwent PCI with second-generation DES between Feb 2009 and Dec 2013. The primary outcomes assessed were two-year major cardiac adverse events (MACE), composite endpoints of dea...

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Published in:PloS one 2020-06, Vol.15 (6), p.e0234362-e0234362
Main Authors: Lee, Cheol Hyun, Choi, Sang-Woong, Jun, Seung-Woon, Hwang, Jongmin, Kim, In-Cheol, Cho, Yun-Kyeong, Park, Hyoung-Seob, Yoon, Hyuck-Jun, Kim, Hyungseop, Nam, Chang-Wook, Han, Seongwook, Kim, Kwon-Bae, Hur, Seung-Ho
Format: Article
Language:English
Subjects:
Balloon angioplasty
Blood vessels
Cardiology
Cardiovascular diseases
Care and treatment
Clinical outcomes
Complications and side effects
Coronary heart disease
Diabetes
Diabetes mellitus
Drug delivery
Drug-eluting stents
Failure analysis
Health risks
Heart attacks
Implantation
Implants
Internal medicine
Medicine
Medicine and Health Sciences
Myocardial infarction
Patient outcomes
Patients
Physical Sciences
Prognosis
Renal failure
Research and Analysis Methods
Risk analysis
Risk factors
Stents
Studies
Surgical implants
Thrombosis
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Summary:Using patient-level data from two stent-specific, all-comer, prospective DES registries, we evaluated 1,913 patients who underwent PCI with second-generation DES between Feb 2009 and Dec 2013. The primary outcomes assessed were two-year major cardiac adverse events (MACE), composite endpoints of death from any cause, myocardial infarction (MI), and any repeat revascularization. We classified 0-1 year as the early period and 1-2 years as the late period. Landmark analyses were performed according to diabetes mellitus status. There were 1,913 patients with 2,614 lesions included in the pooled dataset. The median duration of clinical follow-up in the overall population was 2.0 years (interquartile range 1.9-2.1). Patients with DM had more cardiovascular risk factors than patients without DM. In multivariate analyses, the presence of DM and renal failure were strong predictors of MACE and target-vessel revascularization (TVR). After inverse probability of treatment weighting (IPTW) analyses, patients with DM had significantly increased rates of 2-year MACE (HR 2.07, 95% CI; 1.50-2.86; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0234362