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Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location

Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly underst...

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Bibliographic Details
Published in:PloS one 2020-07, Vol.15 (7), p.e0236375-e0236375
Main Authors: Jabbarzare, Marzieh, Njie, Madi, Jaworowski, Anthony, Umbers, Alexandra J, Ome-Kaius, Maria, Hasang, Wina, Randall, Louise M, Kalionis, Bill, Rogerson, Stephen J
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Language:English
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Summary:Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood. Peripheral blood mononuclear cell responses to Plasmodium falciparum-infected erythrocytes and phytohemagglutinin were compared between pregnant women from Papua New Guinea (malaria-exposed) with and without current malaria infection and from Australia (unexposed). Elicited levels of inflammatory cytokines at 48 h and 24 h (interferon [gamma], IFN-[gamma] only) and the cellular sources of IFN-[gamma] were analysed. Among Papua New Guinean women, microscopic malaria at enrolment did not alter peripheral blood mononuclear cell responses. Compared to samples from Australia, cells from Papua New Guinean women secreted more inflammatory cytokines tumor necrosis factor-[alpha], interleukin 1[beta], interleukin 6 and IFN-[gamma]; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0236375