Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location

Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly underst...

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Published in:PloS one 2020-07, Vol.15 (7), p.e0236375-e0236375
Main Authors: Jabbarzare, Marzieh, Njie, Madi, Jaworowski, Anthony, Umbers, Alexandra J, Ome-Kaius, Maria, Hasang, Wina, Randall, Louise M, Kalionis, Bill, Rogerson, Stephen J
Format: Article
Language:English
Subjects:
Anemia
Binding
Biology and Life Sciences
Blood
CD36 antigen
Complications
Cytokines
Development and progression
Diagnosis
Erythrocytes
Ethics
Fetuses
Geographical locations
Health aspects
Hospitals
Immune response
Immune system
Infections
Inflammation
Innate immunity
Interferon
Interleukin 6
Lymphocytes
Lymphocytes T
Malaria
Medical research
Medicine
Medicine and Health Sciences
Microscopy
Morbidity
Natural killer cells
Neonates
Parasites
Pathogenesis
Peripheral blood
Plasmodium falciparum
Pregnancy
Pregnancy complications
Pregnant women
Proteins
Red blood cells
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vector-borne diseases
Vectors (Biology)
Womens health
γ-Interferon
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creator Jabbarzare, Marzieh
Njie, Madi
Jaworowski, Anthony
Umbers, Alexandra J
Ome-Kaius, Maria
Hasang, Wina
Randall, Louise M
Kalionis, Bill
Rogerson, Stephen J
description Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood. Peripheral blood mononuclear cell responses to Plasmodium falciparum-infected erythrocytes and phytohemagglutinin were compared between pregnant women from Papua New Guinea (malaria-exposed) with and without current malaria infection and from Australia (unexposed). Elicited levels of inflammatory cytokines at 48 h and 24 h (interferon [gamma], IFN-[gamma] only) and the cellular sources of IFN-[gamma] were analysed. Among Papua New Guinean women, microscopic malaria at enrolment did not alter peripheral blood mononuclear cell responses. Compared to samples from Australia, cells from Papua New Guinean women secreted more inflammatory cytokines tumor necrosis factor-[alpha], interleukin 1[beta], interleukin 6 and IFN-[gamma]; p
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The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood. Peripheral blood mononuclear cell responses to Plasmodium falciparum-infected erythrocytes and phytohemagglutinin were compared between pregnant women from Papua New Guinea (malaria-exposed) with and without current malaria infection and from Australia (unexposed). Elicited levels of inflammatory cytokines at 48 h and 24 h (interferon [gamma], IFN-[gamma] only) and the cellular sources of IFN-[gamma] were analysed. Among Papua New Guinean women, microscopic malaria at enrolment did not alter peripheral blood mononuclear cell responses. Compared to samples from Australia, cells from Papua New Guinean women secreted more inflammatory cytokines tumor necrosis factor-[alpha], interleukin 1[beta], interleukin 6 and IFN-[gamma]; p&lt;0.001 for all assays, and more natural killer cells produced IFN-[gamma] in response to infected erythrocytes and phytohemagglutinin. In both populations, cytokine responses were not affected by gravidity, except that in the Papua New Guinean cohort multigravid women had higher IFN-[gamma] secretion at 24 h (p = 0.029) and an increased proportion of IFN-[gamma].sup.+ V[delta]2 [gamma][delta] T cells (p = 0.003). Cytokine levels elicited by a pregnancy malaria-specific CSA binding parasite line, CS2, were broadly similar to those elicited by CD36-binding line P6A1. 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The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood. Peripheral blood mononuclear cell responses to Plasmodium falciparum-infected erythrocytes and phytohemagglutinin were compared between pregnant women from Papua New Guinea (malaria-exposed) with and without current malaria infection and from Australia (unexposed). Elicited levels of inflammatory cytokines at 48 h and 24 h (interferon [gamma], IFN-[gamma] only) and the cellular sources of IFN-[gamma] were analysed. Among Papua New Guinean women, microscopic malaria at enrolment did not alter peripheral blood mononuclear cell responses. Compared to samples from Australia, cells from Papua New Guinean women secreted more inflammatory cytokines tumor necrosis factor-[alpha], interleukin 1[beta], interleukin 6 and IFN-[gamma]; p&lt;0.001 for all assays, and more natural killer cells produced IFN-[gamma] in response to infected erythrocytes and phytohemagglutinin. In both populations, cytokine responses were not affected by gravidity, except that in the Papua New Guinean cohort multigravid women had higher IFN-[gamma] secretion at 24 h (p = 0.029) and an increased proportion of IFN-[gamma].sup.+ V[delta]2 [gamma][delta] T cells (p = 0.003). Cytokine levels elicited by a pregnancy malaria-specific CSA binding parasite line, CS2, were broadly similar to those elicited by CD36-binding line P6A1. Geographic location and, to some extent, gravidity influence maternal innate immunity to malaria.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32726331</pmid><doi>10.1371/journal.pone.0236375</doi><tpages>e0236375</tpages><orcidid>https://orcid.org/0000-0001-7369-9463</orcidid><oa>free_for_read</oa></addata></record>
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1932-6203
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subjects Anemia
Binding
Biology and Life Sciences
Blood
CD36 antigen
Complications
Cytokines
Development and progression
Diagnosis
Erythrocytes
Ethics
Fetuses
Geographical locations
Health aspects
Hospitals
Immune response
Immune system
Infections
Inflammation
Innate immunity
Interferon
Interleukin 6
Lymphocytes
Lymphocytes T
Malaria
Medical research
Medicine
Medicine and Health Sciences
Microscopy
Morbidity
Natural killer cells
Neonates
Parasites
Pathogenesis
Peripheral blood
Plasmodium falciparum
Pregnancy
Pregnancy complications
Pregnant women
Proteins
Red blood cells
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vector-borne diseases
Vectors (Biology)
Womens health
γ-Interferon
title Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location
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