Antibiotic tolerance

[...]in the setting of extreme tolerance (so-called “persistence”), the majority of the population is rapidly killed, but a small subpopulation remains viable for an extended period (orange-colored line). https://doi.org/10.1371/journal.ppat.1008892.g001 Antibiotic stress response and tolerance—Why...

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Bibliographic Details
Published in:PLoS pathogens 2020-10, Vol.16 (10), p.e1008892
Main Authors: Westblade, Lars F, Errington, Jeff, Dörr, Tobias
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotic tolerance
Antibiotics
Bacteria
Bacterial infections
Biological assay
Biology and Life Sciences
Cations
Cellular stress response
Damage
Divalent cations
DNA damage
Drug resistance in microorganisms
Drug Resistance, Bacterial
Drug Tolerance
Enzymes
Evolution, Molecular
Exposure
Heterogeneity
Humans
Innovations
Lysis
Medicine
Medicine and Health Sciences
Microbiological research
Pearls
Peptidoglycans
Phenotypes
Physical Sciences
Population
Stochasticity
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Summary:[...]in the setting of extreme tolerance (so-called “persistence”), the majority of the population is rapidly killed, but a small subpopulation remains viable for an extended period (orange-colored line). https://doi.org/10.1371/journal.ppat.1008892.g001 Antibiotic stress response and tolerance—Why do some cells die and others don’t? Antibiotic tolerance strategies mediated by stress responses are likely operating in a race against time: cells must respond to a potentially lethal insult in sufficient time to mount a response and repair the antibiotic-induced damage. [...]one would predict the magnitude of stochastic stress response induction before antibiotic exposure might be predictive of the probability to survive exposure, which could potentially explain population heterogeneity in survival phenotypes. [...]protection from osmotic lysis, usually requiring an isotonic medium containing a high concentration of divalent cations [18]. [...]protection from damage by endogenous ROS that arise, at least in part, due to the metabolic imbalances that occur when the flux of precursors to peptidoglycan synthesis is diverted [19].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1008892