Predictive value of pulse oximetry for mortality in infants and children presenting to primary care with clinical pneumonia in rural Malawi: A data linkage study

The mortality impact of pulse oximetry use during infant and childhood pneumonia management at the primary healthcare level in low-income countries is unknown. We sought to determine mortality outcomes of infants and children diagnosed and referred using clinical guidelines with or without pulse oxi...

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Bibliographic Details
Published in:PLoS medicine 2020-10, Vol.17 (10), p.e1003300-e1003300
Main Authors: Colbourn, Tim, King, Carina, Beard, James, Phiri, Tambosi, Mdala, Malizani, Zadutsa, Beatiwel, Makwenda, Charles, Costello, Anthony, Lufesi, Norman, Mwansambo, Charles, Nambiar, Bejoy, Hooli, Shubhada, French, Neil, Bar Zeev, Naor, Qazi, Shamim Ahmad, Bin Nisar, Yasir, McCollum, Eric D
Format: Article
Language:English
Subjects:
Age
Biology and Life Sciences
Child, Preschool
Childhood pneumonia
Children & youth
Community Health Workers
Datasets
Death
Fatalities
Female
Hospitalization
Humans
Infant
Infant, Newborn
Infants
Information Storage and Retrieval - methods
Malawi - epidemiology
Male
Medicine and Health Sciences
Methods
Mortality
Odds Ratio
Outpatients
Oximetry
Oximetry - methods
Patient outcomes
Patients
Pediatrics
People and Places
Physical Sciences
Pneumonia
Pneumonia - mortality
Predictive Value of Tests
Primary care
Primary Health Care
Prognosis
Prospective Studies
Pulse oximetry
Rural Population
Signs
Surveillance
Vaccination
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Summary:The mortality impact of pulse oximetry use during infant and childhood pneumonia management at the primary healthcare level in low-income countries is unknown. We sought to determine mortality outcomes of infants and children diagnosed and referred using clinical guidelines with or without pulse oximetry in Malawi. We conducted a data linkage study of prospective health facility and community case and mortality data. We matched prospectively collected community health worker (CHW) and health centre (HC) outpatient data to prospectively collected hospital and community-based mortality surveillance outcome data, including episodes followed up to and deaths within 30 days of pneumonia diagnosis amongst children 0-59 months old. All data were collected in Lilongwe and Mchinji districts, Malawi, from January 2012 to June 2014. We determined differences in mortality rates using
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1003300