Loading…
The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States
This paper estimates the benefits and costs of state suppression policies to "bend the curve" during the initial outbreak of COVID-19 in the United States. We employ an approach that values benefits and costs in terms of additions or subtractions to total production. Relative to a baseline...
Saved in:
Published in: | PloS one 2021-06, Vol.16 (6), p.e0252729-e0252729 |
---|---|
Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53 |
---|---|
cites | cdi_FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53 |
container_end_page | e0252729 |
container_issue | 6 |
container_start_page | e0252729 |
container_title | PloS one |
container_volume | 16 |
creator | Broughel, James Kotrous, Michael |
description | This paper estimates the benefits and costs of state suppression policies to "bend the curve" during the initial outbreak of COVID-19 in the United States. We employ an approach that values benefits and costs in terms of additions or subtractions to total production. Relative to a baseline in which only the infected and at-risk populations mitigate the spread of coronavirus, we estimate that total benefits of suppression policies to economic output are between $632.5 billion and $765.0 billion from early March 2020 to August 1, 2020. Relative to private mitigation, output lost due to suppression policies is estimated to be between $214.2 billion and $331.5 billion. The cost estimate is based on the duration of nonessential business closures and stay-at-home orders, which were enforced between 42 and 65 days. Our results indicate that the net benefits of suppression policies to slow the spread of COVID-19 are positive and may be substantial. We discuss uncertainty surrounding several parameters and employ alternative methods for valuing mortality benefits, which also suggest that suppression measures had positive net benefits. |
doi_str_mv | 10.1371/journal.pone.0252729 |
format | article |
fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2536796600</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A663983582</galeid><doaj_id>oai_doaj_org_article_ede58ac22669494ea1b8910b545ba534</doaj_id><sourcerecordid>A663983582</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53</originalsourceid><addsrcrecordid>eNqNk02P0zAQhiMEYpfCP0AQCQnBoSWOYzvhgFSVr0orVWI_rpbjTFpXaVxsp7Bn_jiTNrtq0R6QD3E8z7zjmfFE0UuSTAgV5MPadq5VzWRrW5gkKUtFWjyKzklB0zFPE_r4aH8WPfN-nSSM5pw_jc5oluREMHEe_blaQVxCC7UJPrZ1rK2zrdoZ1_nYd9utA--NbT_GUzT5MB7YWGHsW2_2PgE1kMObeIiD3f_XxvkQ_1I76InZ4mb-eUyK2LR763VrAlTxZVAB_PPoSa0aDy-G7yi6_vrlavZ9fLH4Np9NL8ZasBwjk7QUZZXzvKQkJ7mqaMoqEHVVYFa6TGmCdg05bjSaiBCYeko4y4QuK0ZH0euD7raxXg718zJllIuC8yRBYn4gKqvWcuvMRrlbaZWR-wPrllK5YHQDEipgudJpynmRFRkoUuYFSUqWsVIxmqHWpyFaV26g0tAGp5oT0VNLa1ZyaXcSO5MJ0gu8GwSc_dmBD3JjvIamUS3Ybn9vwSnFPiL65h_04ewGaqkwAdPWFuPqXlROOadFThnWbhRNHqBwVbAx2vbdx_MTh_cnDsgE-B2WqvNezi9__D-7uDll3x6xK1BNWHnbdAGfoz8FswOonfXeQX1fZJLIflbuqiH7WZHDrKDbq-MG3TvdDQf9C4Q0DfU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2536796600</pqid></control><display><type>article</type><title>The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States</title><source>PubMed (Medline)</source><source>Publicly Available Content Database</source><creator>Broughel, James ; Kotrous, Michael</creator><contributor>Horton, Susan</contributor><creatorcontrib>Broughel, James ; Kotrous, Michael ; Horton, Susan</creatorcontrib><description>This paper estimates the benefits and costs of state suppression policies to "bend the curve" during the initial outbreak of COVID-19 in the United States. We employ an approach that values benefits and costs in terms of additions or subtractions to total production. Relative to a baseline in which only the infected and at-risk populations mitigate the spread of coronavirus, we estimate that total benefits of suppression policies to economic output are between $632.5 billion and $765.0 billion from early March 2020 to August 1, 2020. Relative to private mitigation, output lost due to suppression policies is estimated to be between $214.2 billion and $331.5 billion. The cost estimate is based on the duration of nonessential business closures and stay-at-home orders, which were enforced between 42 and 65 days. Our results indicate that the net benefits of suppression policies to slow the spread of COVID-19 are positive and may be substantial. We discuss uncertainty surrounding several parameters and employ alternative methods for valuing mortality benefits, which also suggest that suppression measures had positive net benefits.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0252729</identifier><identifier>PMID: 34081757</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Benefit cost analysis ; Biology and Life Sciences ; Commerce - economics ; Coronaviruses ; Cost benefit analysis ; Cost control ; Cost-Benefit Analysis - methods ; COVID-19 ; COVID-19 - economics ; Disease control ; Disease transmission ; Educational facilities ; Enforcement ; Evaluation ; GDP ; Gross Domestic Product ; Health promotion ; Health risks ; Human capital ; Humans ; Medicine and Health Sciences ; Mortality ; Opportunity costs ; Pandemics ; People and Places ; Physical Distancing ; Population ; Public health ; Quarantine - economics ; SARS-CoV-2 - pathogenicity ; Shelter in place ; Social distancing ; United States ; Viral diseases</subject><ispartof>PloS one, 2021-06, Vol.16 (6), p.e0252729-e0252729</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Broughel, Kotrous. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Broughel, Kotrous 2021 Broughel, Kotrous</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53</citedby><cites>FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53</cites><orcidid>0000-0002-2586-9082</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2536796600/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2536796600?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34081757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Horton, Susan</contributor><creatorcontrib>Broughel, James</creatorcontrib><creatorcontrib>Kotrous, Michael</creatorcontrib><title>The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This paper estimates the benefits and costs of state suppression policies to "bend the curve" during the initial outbreak of COVID-19 in the United States. We employ an approach that values benefits and costs in terms of additions or subtractions to total production. Relative to a baseline in which only the infected and at-risk populations mitigate the spread of coronavirus, we estimate that total benefits of suppression policies to economic output are between $632.5 billion and $765.0 billion from early March 2020 to August 1, 2020. Relative to private mitigation, output lost due to suppression policies is estimated to be between $214.2 billion and $331.5 billion. The cost estimate is based on the duration of nonessential business closures and stay-at-home orders, which were enforced between 42 and 65 days. Our results indicate that the net benefits of suppression policies to slow the spread of COVID-19 are positive and may be substantial. We discuss uncertainty surrounding several parameters and employ alternative methods for valuing mortality benefits, which also suggest that suppression measures had positive net benefits.</description><subject>Benefit cost analysis</subject><subject>Biology and Life Sciences</subject><subject>Commerce - economics</subject><subject>Coronaviruses</subject><subject>Cost benefit analysis</subject><subject>Cost control</subject><subject>Cost-Benefit Analysis - methods</subject><subject>COVID-19</subject><subject>COVID-19 - economics</subject><subject>Disease control</subject><subject>Disease transmission</subject><subject>Educational facilities</subject><subject>Enforcement</subject><subject>Evaluation</subject><subject>GDP</subject><subject>Gross Domestic Product</subject><subject>Health promotion</subject><subject>Health risks</subject><subject>Human capital</subject><subject>Humans</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Opportunity costs</subject><subject>Pandemics</subject><subject>People and Places</subject><subject>Physical Distancing</subject><subject>Population</subject><subject>Public health</subject><subject>Quarantine - economics</subject><subject>SARS-CoV-2 - pathogenicity</subject><subject>Shelter in place</subject><subject>Social distancing</subject><subject>United States</subject><subject>Viral diseases</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02P0zAQhiMEYpfCP0AQCQnBoSWOYzvhgFSVr0orVWI_rpbjTFpXaVxsp7Bn_jiTNrtq0R6QD3E8z7zjmfFE0UuSTAgV5MPadq5VzWRrW5gkKUtFWjyKzklB0zFPE_r4aH8WPfN-nSSM5pw_jc5oluREMHEe_blaQVxCC7UJPrZ1rK2zrdoZ1_nYd9utA--NbT_GUzT5MB7YWGHsW2_2PgE1kMObeIiD3f_XxvkQ_1I76InZ4mb-eUyK2LR763VrAlTxZVAB_PPoSa0aDy-G7yi6_vrlavZ9fLH4Np9NL8ZasBwjk7QUZZXzvKQkJ7mqaMoqEHVVYFa6TGmCdg05bjSaiBCYeko4y4QuK0ZH0euD7raxXg718zJllIuC8yRBYn4gKqvWcuvMRrlbaZWR-wPrllK5YHQDEipgudJpynmRFRkoUuYFSUqWsVIxmqHWpyFaV26g0tAGp5oT0VNLa1ZyaXcSO5MJ0gu8GwSc_dmBD3JjvIamUS3Ybn9vwSnFPiL65h_04ewGaqkwAdPWFuPqXlROOadFThnWbhRNHqBwVbAx2vbdx_MTh_cnDsgE-B2WqvNezi9__D-7uDll3x6xK1BNWHnbdAGfoz8FswOonfXeQX1fZJLIflbuqiH7WZHDrKDbq-MG3TvdDQf9C4Q0DfU</recordid><startdate>20210603</startdate><enddate>20210603</enddate><creator>Broughel, James</creator><creator>Kotrous, Michael</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2586-9082</orcidid></search><sort><creationdate>20210603</creationdate><title>The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States</title><author>Broughel, James ; Kotrous, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Benefit cost analysis</topic><topic>Biology and Life Sciences</topic><topic>Commerce - economics</topic><topic>Coronaviruses</topic><topic>Cost benefit analysis</topic><topic>Cost control</topic><topic>Cost-Benefit Analysis - methods</topic><topic>COVID-19</topic><topic>COVID-19 - economics</topic><topic>Disease control</topic><topic>Disease transmission</topic><topic>Educational facilities</topic><topic>Enforcement</topic><topic>Evaluation</topic><topic>GDP</topic><topic>Gross Domestic Product</topic><topic>Health promotion</topic><topic>Health risks</topic><topic>Human capital</topic><topic>Humans</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Opportunity costs</topic><topic>Pandemics</topic><topic>People and Places</topic><topic>Physical Distancing</topic><topic>Population</topic><topic>Public health</topic><topic>Quarantine - economics</topic><topic>SARS-CoV-2 - pathogenicity</topic><topic>Shelter in place</topic><topic>Social distancing</topic><topic>United States</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broughel, James</creatorcontrib><creatorcontrib>Kotrous, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broughel, James</au><au>Kotrous, Michael</au><au>Horton, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-06-03</date><risdate>2021</risdate><volume>16</volume><issue>6</issue><spage>e0252729</spage><epage>e0252729</epage><pages>e0252729-e0252729</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This paper estimates the benefits and costs of state suppression policies to "bend the curve" during the initial outbreak of COVID-19 in the United States. We employ an approach that values benefits and costs in terms of additions or subtractions to total production. Relative to a baseline in which only the infected and at-risk populations mitigate the spread of coronavirus, we estimate that total benefits of suppression policies to economic output are between $632.5 billion and $765.0 billion from early March 2020 to August 1, 2020. Relative to private mitigation, output lost due to suppression policies is estimated to be between $214.2 billion and $331.5 billion. The cost estimate is based on the duration of nonessential business closures and stay-at-home orders, which were enforced between 42 and 65 days. Our results indicate that the net benefits of suppression policies to slow the spread of COVID-19 are positive and may be substantial. We discuss uncertainty surrounding several parameters and employ alternative methods for valuing mortality benefits, which also suggest that suppression measures had positive net benefits.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34081757</pmid><doi>10.1371/journal.pone.0252729</doi><tpages>e0252729</tpages><orcidid>https://orcid.org/0000-0002-2586-9082</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2021-06, Vol.16 (6), p.e0252729-e0252729 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_2536796600 |
source | PubMed (Medline); Publicly Available Content Database |
subjects | Benefit cost analysis Biology and Life Sciences Commerce - economics Coronaviruses Cost benefit analysis Cost control Cost-Benefit Analysis - methods COVID-19 COVID-19 - economics Disease control Disease transmission Educational facilities Enforcement Evaluation GDP Gross Domestic Product Health promotion Health risks Human capital Humans Medicine and Health Sciences Mortality Opportunity costs Pandemics People and Places Physical Distancing Population Public health Quarantine - economics SARS-CoV-2 - pathogenicity Shelter in place Social distancing United States Viral diseases |
title | The benefits of coronavirus suppression: A cost-benefit analysis of the response to the first wave of COVID-19 in the United States |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A18%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20benefits%20of%20coronavirus%20suppression:%20A%20cost-benefit%20analysis%20of%20the%20response%20to%20the%20first%20wave%20of%20COVID-19%20in%20the%20United%20States&rft.jtitle=PloS%20one&rft.au=Broughel,%20James&rft.date=2021-06-03&rft.volume=16&rft.issue=6&rft.spage=e0252729&rft.epage=e0252729&rft.pages=e0252729-e0252729&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0252729&rft_dat=%3Cgale_plos_%3EA663983582%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c758t-b12b7bd868b31818ad325de7fd9866cb230b7bce8230c325177203216547cbd53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2536796600&rft_id=info:pmid/34081757&rft_galeid=A663983582&rfr_iscdi=true |