Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of...

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Published in:PLoS neglected tropical diseases 2021-06, Vol.15 (6), p.e0009452-e0009452
Main Authors: Kajihara, Masahiro, Simuunza, Martin, Saasa, Ngonda, Dautu, George, Mori-Kajihara, Akina, Qiu, Yongjin, Nakao, Ryo, Eto, Yoshiki, Furumoto, Hayato, Hang’ombe, Bernard M., Orba, Yasuko, Sawa, Hirofumi, Simulundu, Edgar, Fukushi, Shuetsu, Morikawa, Shigeru, Saijo, Masayuki, Arikawa, Jiro, Kabilika, Swithine, Monze, Mwaka, Mukonka, Victor, Mweene, Aaron, Takada, Ayato, Yoshimatsu, Kumiko
Format: Article
Language:English
Subjects:
Animals
Annealing
Arachnids
Biology and Life Sciences
Cattle
Computer and Information Sciences
Crimean hemorrhagic fever
Disease transmission
Distribution
Epidemiology
Fever
Genetic aspects
Genetic diversity
Genetic variation
Genomes
Genotype
Haemorrhage
Health aspects
Hemorrhage
Identification and classification
Immunofluorescence
Immunoglobulin G
Infections
Infectious diseases
Laboratories
Medicine and health sciences
Methods
Microbiological strains
People and Places
Phylogeny
Risk assessment
RNA polymerase
Sentinel health events
Serum
Strains
Ticks
Transmission
Tropical diseases
Vertebrates
Veterinary medicine
Virus-vector relationships
Viruses
Zoonoses
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cited_by cdi_FETCH-LOGICAL-c711t-8a2e338052620b93b8779b8ad79d7f879deb433ce4cd4134ff53c546202cdec33
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container_end_page e0009452
container_issue 6
container_start_page e0009452
container_title PLoS neglected tropical diseases
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creator Kajihara, Masahiro
Simuunza, Martin
Saasa, Ngonda
Dautu, George
Mori-Kajihara, Akina
Qiu, Yongjin
Nakao, Ryo
Eto, Yoshiki
Furumoto, Hayato
Hang’ombe, Bernard M.
Orba, Yasuko
Sawa, Hirofumi
Simulundu, Edgar
Fukushi, Shuetsu
Morikawa, Shigeru
Saijo, Masayuki
Arikawa, Jiro
Kabilika, Swithine
Monze, Mwaka
Mukonka, Victor
Mweene, Aaron
Takada, Ayato
Yoshimatsu, Kumiko
description Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts.
doi_str_mv 10.1371/journal.pntd.0009452
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titles)</collection><collection>Directory of Open Access Journals(OpenAccess)</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kajihara, Masahiro</au><au>Simuunza, Martin</au><au>Saasa, Ngonda</au><au>Dautu, George</au><au>Mori-Kajihara, Akina</au><au>Qiu, Yongjin</au><au>Nakao, Ryo</au><au>Eto, Yoshiki</au><au>Furumoto, Hayato</au><au>Hang’ombe, Bernard M.</au><au>Orba, Yasuko</au><au>Sawa, Hirofumi</au><au>Simulundu, Edgar</au><au>Fukushi, Shuetsu</au><au>Morikawa, Shigeru</au><au>Saijo, Masayuki</au><au>Arikawa, Jiro</au><au>Kabilika, Swithine</au><au>Monze, Mwaka</au><au>Mukonka, Victor</au><au>Mweene, Aaron</au><au>Takada, Ayato</au><au>Yoshimatsu, Kumiko</au><au>Klingström, Jonas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia</atitle><jtitle>PLoS neglected tropical diseases</jtitle><date>2021-06-01</date><risdate>2021</risdate><volume>15</volume><issue>6</issue><spage>e0009452</spage><epage>e0009452</epage><pages>e0009452-e0009452</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34061841</pmid><doi>10.1371/journal.pntd.0009452</doi><orcidid>https://orcid.org/0000-0001-6190-428X</orcidid><orcidid>https://orcid.org/0000-0001-6249-6716</orcidid><orcidid>https://orcid.org/0000-0003-2464-6642</orcidid><orcidid>https://orcid.org/0000-0001-9423-0816</orcidid><orcidid>https://orcid.org/0000-0002-0062-2753</orcidid><orcidid>https://orcid.org/0000-0003-2569-2755</orcidid><orcidid>https://orcid.org/0000-0001-6470-4582</orcidid><orcidid>https://orcid.org/0000-0001-5458-7298</orcidid><orcidid>https://orcid.org/0000-0002-8766-6483</orcidid><orcidid>https://orcid.org/0000-0001-6621-7470</orcidid><orcidid>https://orcid.org/0000-0001-8621-5472</orcidid><orcidid>https://orcid.org/0000-0001-9910-3912</orcidid><orcidid>https://orcid.org/0000-0003-4540-6138</orcidid><orcidid>https://orcid.org/0000-0002-3105-7603</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1935-2735
ispartof PLoS neglected tropical diseases, 2021-06, Vol.15 (6), p.e0009452-e0009452
issn 1935-2735
1935-2727
1935-2735
language eng
recordid cdi_plos_journals_2552289213
source NCBI_PubMed Central（免费）; ProQuest Publicly Available Content database
subjects Animals
Annealing
Arachnids
Biology and Life Sciences
Cattle
Computer and Information Sciences
Crimean hemorrhagic fever
Disease transmission
Distribution
Epidemiology
Fever
Genetic aspects
Genetic diversity
Genetic variation
Genomes
Genotype
Haemorrhage
Health aspects
Hemorrhage
Identification and classification
Immunofluorescence
Immunoglobulin G
Infections
Infectious diseases
Laboratories
Medicine and health sciences
Methods
Microbiological strains
People and Places
Phylogeny
Risk assessment
RNA polymerase
Sentinel health events
Serum
Strains
Ticks
Transmission
Tropical diseases
Vertebrates
Veterinary medicine
Virus-vector relationships
Viruses
Zoonoses
title Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia
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