Toe pressure and toe brachial index are predictive of cardiovascular mortality regardless of the most diseased arterial segment in symptomatic lower-extremity artery disease-A retrospective cohort study

Although lower extremity arterial disease (LEAD) is most often multisegmental, the predominant disease location and risk factors differ between patients. Ankle-brachial index (ABI), toe-brachial index (TBI), and toe pressure (TP) are predictive of outcome in LEAD patients. Previously, we reported a...

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Bibliographic Details
Published in:PloS one 2021-11, Vol.16 (11), p.e0259122
Main Authors: Koivunen, V, Juonala, M, Venermo, M, Laivuori, M, Jalkanen, J M, Hakovirta, H H
Format: Article
Language:English
Subjects:
Aged
Angiography
Ankle
Ankle Brachial Index
Atherosclerosis
Biology and Life Sciences
Blood Pressure
Brachial artery
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
Care and treatment
Chronic obstructive pulmonary disease
Classification
Cohort analysis
Diabetes
Diagnosis
Diagnostic imaging
Ethics
Female
Health risks
Hospitals
Humans
Hypertension
Ischemia
Laboratories
Lower Extremity - blood supply
Lower Extremity - physiopathology
Male
Medical examination
Medicine
Medicine and Health Sciences
Methods
Middle Aged
Mortality
Patient outcomes
Patients
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - mortality
Peripheral Arterial Disease - physiopathology
Pressure
Pressure measurement
Pressure measurements
Regression analysis
Regulation
Retrospective Studies
Risk analysis
Risk Factors
Segments
Toe
Toes - blood supply
Vascular surgery
Vein & artery diseases
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Summary:Although lower extremity arterial disease (LEAD) is most often multisegmental, the predominant disease location and risk factors differ between patients. Ankle-brachial index (ABI), toe-brachial index (TBI), and toe pressure (TP) are predictive of outcome in LEAD patients. Previously, we reported a classification method defining the most diseased arterial segment (MDAS); crural (CR), femoropopliteal (FP), or aortoiliac (AOI). Current study aimed to analyze the associations between MDAS, peripheral pressure measurements and cardiovascular mortality. We reviewed retrospectively 729 consecutive LEAD patients (Rutherford 2-6) who underwent digital subtraction angiography between January, 2009 to August, 2011 and had standardized peripheral pressure measurements. In Cox Regression analyses, cardiovascular mortality was associated with MDAS and non-invasive pressure indices as follows; MDAS AOI, TP
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0259122