Type 1 and type 2 diabetes mellitus: Clinical outcomes due to COVID-19. Protocol of a systematic literature review

• Published in: PloS one 2022-09, Vol.17 (9), p.e0271851-e0271851
• Main Authors: Pérez Bedoya, Juan Pablo, Mejía Muñoz, Alejandro, Barengo, Noël Christopher, Diaz Valencia, Paula Andrea
• Format: Article
• Language: English
• Subjects: Bibliographic data bases; Care and treatment; Clinical outcomes; Complications; Coronaviruses; COVID-19; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Disease; Gestational diabetes; Glucose; Grey literature; Infections; Literature reviews; Medical research; Medicine and Health Sciences; Mortality; Observational studies; Patient outcomes; Patients; Physical Sciences; Quality assessment; Quality control; Registered Report Protocol; Research and Analysis Methods; Severe acute respiratory syndrome coronavirus 2; Synthesis; Systematic review; Type 1 diabetes; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0271851

Diabetes has been associated with an increased risk of complications in patients with COVID-19. Most studies do not differentiate between patients with type 1 and type 2 diabetes, which correspond to two pathophysiological distinct diseases that could represent different degrees of clinical compromise. To identify if there are differences in the clinical outcomes of patients with COVID-19 and diabetes (type 1 and type 2) compared to patients with COVID-19 without diabetes. Observational studies of patients with COVID-19 and diabetes (both type 1 and type 2) will be included without restriction of geographic region, gender or age, whose outcome is hospitalization, admission to intensive care unit or mortality compared to patients without diabetes. Two authors will independently perform selection, data extraction, and quality assessment, and a third reviewer will resolve discrepancies. The data will be synthesized regarding the sociodemographic and clinical characteristics of patients with diabetes and without diabetes accompanied by the measure of association for the outcomes. The data will be synthesized regarding the sociodemographic and clinical characteristics of patients with diabetes and without diabetes accompanied by the measure of association for the outcomes. This study was registered at the International Prospective Registry for Systematic Reviews (PROSPERO)-CRD42021231942.