Digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children 1–3 years old at a rural facility, Bangladesh: Results from a four arm exploratory study

Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children. Sixty children of either sex, aged 1-3 years having fo...

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Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0274302-e0274302
Main Authors: Shahid, Abu Sadat Mohammad Sayeem Bin, Ahmed, Shahnawaz, Renesa, Tanzina Tazul, Onni, Anindita Tasnim, Dash, Sampa, Kishimoto, Yuka, Kanahori, Sumiko, Ahmed, Tahmeed, Faruque, Abu Syed Golam, Chisti, Mohammod Jobayer
Format: Article
Language:English
Subjects:
Abdomen
Acceptability
Bacteria
Biology and Life Sciences
Caregivers
Children
Children & youth
Clinical trials
Consent
Data collection
Diarrhea
Dietary fiber
Distension
Drinking water
Enrollments
Hospitals
Intervention
Interviews
Large intestine
Medicine and Health Sciences
Pain
Parents & parenting
Pediatric research
People and Places
Prebiotics
Prevention
Questionnaires
Rural areas
Sociodemographics
Socioeconomic factors
Statistical analysis
Statistics
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Summary:Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children. Sixty children of either sex, aged 1-3 years having four groups (healthy children/low dose, healthy children/high dose, children with diarrhea/low dose and children with diarrhea/high dose) were enrolled into this exploratory study between 1.sup.st August to 23.sup.rd October 2017. Two presumptive doses, low (2.5g) and high (5g), twice daily with 50 ml drinking water for seven days were the interventions. Outcomes were to observe the development of possible abdominal symptoms, such as pain, distension, rumbling, and bloating during the intervention and post-intervention periods in healthy and diarrheal children as well as improvement in stool consistencies in diarrheal children. Among the diarrheal children, the median (IQR) duration of resolution of diarrhea was 3.9 (2.9, 5.1) days vs. 3.5 (2.0, 8.0) days, p = 0.885; in low dose and high dose groups, respectively. Significant difference was observed in terms of abdominal pain (27% vs. 7%, p = 0.038) and distension (40% vs. 0%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0274302