Modeling Candida auris skin colonization: Mice, swine, and humans

Since identification in 2009, C. auris has rapidly spread around the world, now accounting for 20% to 30% of Candida bloodstream infections in some healthcare settings [6,7]. In a study of critically ill patients admitted to an intensive care unit, C. auris bloodstream infection developed in approxi...

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Bibliographic Details
Published in:PLoS pathogens 2022-09, Vol.18 (9), p.e1010730-e1010730
Main Authors: Eix, Emily F, Nett, Jeniel E
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Colonization
Drug resistance
Ecology and Environmental Sciences
Fungal infections
Gene expression
Infections
Infectious skin diseases
Medicine and Health Sciences
Methicillin
Ostomy
Pathogens
Patients
Pearls
Prevention
Research and Analysis Methods
Risk factors
Skin
Staphylococcus infections
Swine
Virulence
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Summary:Since identification in 2009, C. auris has rapidly spread around the world, now accounting for 20% to 30% of Candida bloodstream infections in some healthcare settings [6,7]. In a study of critically ill patients admitted to an intensive care unit, C. auris bloodstream infection developed in approximately 25% of patients within 60 days following skin colonization [8]. C. auris frequently colonizes the axilla and groin, sites typically sampled in the screening of patients for resistant bacteria, including methicillin-resistant Staphylococcus aureus [9–11]. Transcriptional studies revealed changes to host gene expression in a C. auris colonized wound as well as up-regulated C. auris virulence genes in this 3D coculture system [25].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010730