Evaluation of barometric whole-body plethysmography for therapy monitoring in cats with feline lower airway disease

Objectives Feline lower airway disease (FLAD) is a common respiratory condition in cats. Traditionally, response to therapy is monitored only by evaluation of clinical signs and radiographic examination of the lungs. Barometric whole-body plethysmography (BWBP) is considered a non-invasive, well-tol...

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Bibliographic Details
Published in:PloS one 2022-10, Vol.17 (10), p.e0276927-e0276927
Main Authors: Gareis, Hannah, Hörner-Schmid, Lina, Zablotski, Yury, Palic, Jelena, Schulz, Bianka
Format: Article
Language:English
Subjects:
Airway management
Allergic diseases
Asthma
Barometers
Biology and Life Sciences
Bronchoconstriction
Bronchus
Cats
Diseases
Evaluation
Granulocytes
Health aspects
Health services
Hematology
Infections
Inflammation
Lavage
Lungs
Medicine and Health Sciences
Methods
Monitoring
Neutrophils
Noninvasive evaluation
Parameters
Plethysmography
Pulmonary function tests
Pulmonary functions
Questionnaires
Respiratory diseases
Respiratory function
Respiratory tract diseases
Spirometry
Steroids
Telemedicine
Therapy
Veterinary medicine
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Summary:Objectives Feline lower airway disease (FLAD) is a common respiratory condition in cats. Traditionally, response to therapy is monitored only by evaluation of clinical signs and radiographic examination of the lungs. Barometric whole-body plethysmography (BWBP) is considered a non-invasive, well-tolerated form of measuring airway reactivity in cats. The aim of the study was to assess pulmonary function testing by BWBP for non-invasive evaluation of response to therapy in cats with FLAD and to investigate whether BWBP parameters correlate with clinical severity. Material and methods The prospective study included 25 client-owned cats, diagnosed with FLAD on the basis of their medical history, clinical signs, radiographic findings, and bronchoalveolar lavage fluid (BALF) examination. At three time points (day 0, 14, and 60), a standardised owner questionnaire, a clinical examination and BWBP measurements were carried out. Results of the questionnaire and the clinical examination were evaluated using a clinical 12-point score. Individual therapy was administered to all patients after diagnosis, based on the severity of disease and compliance of the cat. Results The total clinical score significantly improved over the entire study period (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0276927