Impairment in quantitative microvascular function in non-ischemic cardiomyopathy as demonstrated using cardiovascular magnetic resonance

Microvascular dysfunction (MVD) is present in various cardiovascular diseases and portends worse outcomes. We assessed the prevalence of MVD in patients with non-ischemic cardiomyopathy (NICM) as compared to subjects with preserved ejection fraction (EF) using stress cardiovascular magnetic resonanc...

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Bibliographic Details
Published in:PloS one 2022-11, Vol.17 (11), p.e0264454-e0264454
Main Authors: Slivnick, Jeremy A, Zareba, Karolina M, Truong, Vien T, Liu, Ellen, Barnes, Alexis, Mazur, Wojciech, Binkley, Philip
Format: Article
Language:English
Subjects:
Adenosine
Age
Biology and Life Sciences
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Complications and side effects
Coronary vessels
Diabetes
Diabetes mellitus
Diagnosis
Diuretics
Ejection fraction
Gadolinium
Heart
Heart attacks
Heart diseases
Heart failure
Hypertension
Ischemia
Magnetic resonance
Magnetic resonance imaging
Males
Medical imaging
Medicine and Health Sciences
Microcirculation disorders
Microvasculature
Minority & ethnic groups
Patients
Perfusion
Physical Sciences
Resonance
Risk factors
Slopes
Stress
Vein & artery diseases
Ventricle
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Summary:Microvascular dysfunction (MVD) is present in various cardiovascular diseases and portends worse outcomes. We assessed the prevalence of MVD in patients with non-ischemic cardiomyopathy (NICM) as compared to subjects with preserved ejection fraction (EF) using stress cardiovascular magnetic resonance (CMR). We retrospectively studied consecutive patients with NICM and 58 subjects with preserved left ventricular (LV) EF who underwent stress CMR between 2011-2016. MVD was defined visually as presence of a subendocardial perfusion defect and semiquantitatively by myocardial perfusion reserve index (MPRI
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0264454