Gut microbiome alterations in preclinical Alzheimer's disease

Although some human studies have reported gut microbiome changes in individuals with Alzheimer's disease (AD) dementia or mild cognitive impairment (MCI), gut microbiome alterations in preclinical AD, i.e., cerebral amyloidosis without cognitive impairment, is largely unknown. We aimed to ident...

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Bibliographic Details
Published in:PloS one 2022-11, Vol.17 (11), p.e0278276-e0278276
Main Authors: Jung, Joon Hyung, Kim, Gihyeon, Byun, Min Soo, Lee, Jun Ho, Yi, Dahyun, Park, Hansoo, Lee, Dong Young
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - genetics
Alzheimer's disease
Alzheimers disease
Amyloid beta-protein
Amyloidosis
Animals
Biology and Life Sciences
Clostridium
Cognitive ability
Cognitive Dysfunction
Dementia
Dementia disorders
Deoxyribonucleic acid
Deposition
Development and progression
Digestive organs
Digestive system
DNA
Emission analysis
Gastrointestinal Microbiome - genetics
Genera
Health aspects
Humans
Impairment
Intestinal microflora
Medicine and Health Sciences
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Neurodegenerative diseases
Nucleotide sequence
Obesity
Older people
Pathology
Physiological aspects
Positron emission
Positron emission tomography
Quality control
Retention
RNA, Ribosomal, 16S - genetics
rRNA 16S
Statistical models
Tomography, X-Ray Computed
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Summary:Although some human studies have reported gut microbiome changes in individuals with Alzheimer's disease (AD) dementia or mild cognitive impairment (MCI), gut microbiome alterations in preclinical AD, i.e., cerebral amyloidosis without cognitive impairment, is largely unknown. We aimed to identify gut microbial alterations associated with preclinical AD by comparing cognitively normal (CN) older adults with cerebral Aβ deposition (Aβ+ CN) and those without cerebral Aβ deposition (Aβ- CN). Seventy-eight CN older participants (18 Aβ+ CN and 60 Aβ- CN) were included, and all participants underwent clinical assessment and Pittsburg compound B-positron emission tomography. The V3-V4 region of the 16S rRNA gene of genomic DNA extracted from feces was amplified and sequenced to establish the microbial community. Generalized linear model analysis revealed that the genera Megamonas (B = 3.399, q
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0278276