Impact of dedicated neuro-anesthesia management on clinical outcomes in glioblastoma patients: A single-institution cohort study

Glioblastomas are mostly resected under general anesthesia under the supervision of a general anesthesiologist. Currently, it is largely unkown if clinical outcomes of GBM patients can be improved by appointing a neuro-anesthesiologist for their cases. We aimed to evaluate whether the assignment of...

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Published in:PloS one 2022-12, Vol.17 (12), p.e0278864-e0278864
Main Authors: Gerritsen, Jasper Kees Wim, Rizopoulos, Dimitris, Schouten, Joost Willem, Haitsma, Iain Kristian, Eralp, Ismail, Klimek, Markus, Dirven, Clemens Maria Franciscus, Vincent, Arnaud Jean Pierre Edouard
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia, General
Brain cancer
Brain research
Care and treatment
Clinical outcomes
Cohort analysis
Cohort Studies
Complications
Complications and side effects
Glioblastoma
Glioblastoma - surgery
Glioblastoma multiforme
Humans
Independent variables
Medical personnel
Medical prognosis
Medicine and Health Sciences
Narcotics
Neurological complications
Neurosurgery
Patient outcomes
Patients
People and Places
Postoperative Complications
Prospective Studies
Retrospective Studies
Scholarships & fellowships
Surgery
Teams
Tumors
Variables
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Summary:Glioblastomas are mostly resected under general anesthesia under the supervision of a general anesthesiologist. Currently, it is largely unkown if clinical outcomes of GBM patients can be improved by appointing a neuro-anesthesiologist for their cases. We aimed to evaluate whether the assignment of dedicated neuro-anesthesiologists improves the outcomes of these patients. We also investigated the value of dedicated neuro-oncological surgical teams as an independent variable in both groups. A cohort consisting of 401 GBM patients who had undergone resection was retrospectively investigated. Primary outcomes were postoperative neurological complications, fluid balance, length-of-stay and overall survival. Secondary outcomes were blood loss, anesthesia modality, extent of resection, total admission costs, and duration of surgery. 320 versus 81 patients were operated under the anesthesiological supervision of a general anesthesiologist and a dedicated neuro-anesthesiologist, respectively. Dedicated neuro-anesthesiologists yielded significant superior outcomes in 1) postoperative neurological complications (early: p = 0.002, OR = 2.54; late: p = 0.003, OR = 2.24); 2) fluid balance (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0278864