Evaluation of Triclosan coated suture in obstetrical surgery: A prospective randomized controlled study (NCT05330650)

To assess the effectiveness of Triclosan coated suture in reducing surgical site infections (SSIs) rate after caesarian delivery (CD). Three hundred eighty patients were randomly assigned to closure with polyglactin non coated suture VICRYL, or with polyglactin coated suture VICRYL Plus after caesar...

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Published in:PloS one 2022-12, Vol.17 (12), p.e0278939-e0278939
Main Authors: Mbarki, Wael, Bettaieb, Hajer, Souayeh, Nesrine, Laabidi, Idriss, Rouis, Hadhemi, Halouani, Soumaya, Boufarghine, Rami, Bouyahia, Maha, Bouhmida, Rahma, Ouederni, Mariem, Ben Amor, Anissa, Chermiti, Amal, Laamiri, Hadir, Lika, Amira, Chaibi, Imen, Oueslati, Hedhili, Hsayaoui, Najeh, Mbarki, Chaouki
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - therapeutic use
Antimicrobial agents
Biology and Life Sciences
Care and treatment
Coatings
Complications
Dehiscence
Edema
Effectiveness
Female
Gestational diabetes
Health risks
Hematoma
Hospitals
Humans
Infectious diseases
Medicine and Health Sciences
Obstetric Surgical Procedures
Obstetrics
Patients
People and Places
Performance evaluation
Physical Sciences
Polyglactin 910
Pregnancy
Prospective Studies
Research and Analysis Methods
Risk factors
Statistical analysis
Surgery
Surgical site infections
Surgical Wound Infection - prevention & control
Surgical wound infections
Sutures
Triclosan
Triclosan - therapeutic use
Variables
Wound healing
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Summary:To assess the effectiveness of Triclosan coated suture in reducing surgical site infections (SSIs) rate after caesarian delivery (CD). Three hundred eighty patients were randomly assigned to closure with polyglactin non coated suture VICRYL, or with polyglactin coated suture VICRYL Plus after caesarian section. The primary outcome was the rate of SSIs within 30 days after surgery and secondary outcomes were the rate of wound healing complications. SSI rate was 2.5% in Triclosan group compared to 8.1% with non-coated suture. Use of Triclosan coated suture (TCS) was associated with 69% reduction in SSI rate (p = 0.037; ORa:0.294; 95% CI:0.094-0.921). The use of Triclosan coated suture was associated with statistically lower risk of wound oedema (2.5% vs 10%), (p = 0.019; OR:0.595), dehiscence (3.8% vs 10.6%), (p = 0.023; OR:0.316) and hematoma (p = 0.035; OR:0.423). Our results confirm the effectiveness of Triclosan coated suture in reducing SSI rate and wound healing disturbances. Registered at ClinicalTrials.gov / ID (NCT05330650).
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0278939