Reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters

JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The authors report no other conflict of interest. Since the start of the COVID-19 pandemic, Severe Acute Respiratory Syndrome Corona...

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Bibliographic Details
Published in:PLoS pathogens 2022-12, Vol.18 (12), p.e1010970-e1010970
Main Authors: Boon, Adrianus C M, Darling, Tamarand L, Halfmann, Peter J, Franks, John, Webby, Richard J, Barouch, Dan H, Port, Julia R, Munster, Vincent J, Diamond, Michael S, Kawaoka, Yoshihiro
Format: Article
Language:English
Subjects:
Airborne infection
Allergies
Animal experimentation
Animal models in research
Animals
Biology and Life Sciences
Conflicts of interest
Coronaviruses
COVID-19
Cricetinae
Disease transmission
Funding
Hamsters
Infectious diseases
Influenza
Intermediates
Laboratories
Medical research
Medicine and health sciences
Medicine, Experimental
Mesocricetus
Methods
Mutation
Opinion
Pandemics
Physiological aspects
Proteins
R&D
Research & development
Research and Analysis Methods
Respiratory Aerosols and Droplets
SARS-CoV-2
Seroconversion
Severe acute respiratory syndrome coronavirus 2
Spike protein
Vaccines
Viral diseases
Viruses
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Summary:JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The authors report no other conflict of interest. Since the start of the COVID-19 pandemic, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused hundreds of millions of infections worldwide with more than 6.5 million confirmed deaths. Transmission of SARS-CoV-2 can be established by detection of viral RNA, RNA replication intermediates, viable infectious virus, or seroconversion, with the latter two metrics being the most stringent. Since January 2021, the National Institutes of Health SARS-CoV-2 Assessment of Variant Evolution (SAVE) initiative has evaluated the transmission potential of SARS-CoV-2 variants in Syrian hamsters [16]. [...]it is possible that the changes in the spike protein of Omicron affect and reduce stability of the virus in the infected hosts.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010970